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Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors

Turkan, Fiket; Çetin, Adnan; Taslimi, Parham; Karaman, Muhammet; Gülçin, İlhami (Elsevier, 2019-05)
Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials

Genç Bilgiçli, Hayriye; Kestane, Ali; Taslimi, Parham; Karabay, Oguz; Bytyqi-Damoni, Arlinda; Zengin, Mustafa; Gulçin, İlhami (Elsevier, 2019-04-16)
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes

Kucukoglu, Kaan; Gul, Halise Inci; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Bioorganic Chemistry, 2019-02-04)
Synthesis, characterization, molecular docking, and biological activities of novel pyrazoline derivatives

Turkan, Fikret; Cetin, Adnan; Taslimi, Parham; HKaraman, alide S.; Gulçin, İlhami (Wiley, 2019)
Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects

Cetin, Adnan; Türkan, Fikret; Taslimi, Parham; Gulçin, İlhami (Wiley, 2019-03)
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products

Bayrak, Cetin; Taslimi, Parham; Karaman, Halide Sedef; Gulcin, Ilhami; Menzek, Abdullah (Bioorganic Chemistry, 2019-04)
Novel benzylic substituted imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts: potent carbonic anhydrase and acetylcholinesterase inhibitors

Yigit, Beyhan; Yigit, Murat; Celepci, Duygu Barut; Gok, Yetkin; Aktas, Aydin; Aygun, Muhittin; Taslimi, Parham; Gulcin, Ilhami Ilhami (2018-07-23)
Meta-Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, -glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties

Turker, Ferhat; Celepci, Duygu Barut; Celepci, Duygu Barut; Aktaş, Aydın; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Gülçin, İlhami (Wiley, 2018-07)
Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties

Daryadel, Shahla; Atmaca, Ufuk; Taslimi, Parham; Gülçin, İlhami; Çelik, Murat (Wiley, 2018-11)
Multiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer’s disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α‐glycosidase, α‐amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against α‐glycosidase and 3.3 nM against α‐amylase, respectively. In contrast, Ki values were found of 50.96 ± 2.18 μM against AChE and 53.17 ± 4.47 μM against BChE. α‐Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.

Kaya, Ruya; Taslimi, Parham; Naldan, Muhammet Emin; Gulçin, İlhami (Bentham Science, 2019)

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BARTIN ÜNİVERSİTESİ
Kurumsal Akademik Arşivi

| POLİTİKA | REHBER | İLETİŞİM |

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- Acetylcholinesterase (26)
- Enzyme inhibition (26)
- Carbonic anhydrase (23)
- Butyrylcholinesterase (10)
- Antioxidant activity (3)
- Bromination (2)
- Bromophenols (2)
- Enzyme purification (2)
- Schiff bases (2)
- α-glycosidase (2)
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Date Issued
- 2019 (7)
- 2018 (11)
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