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Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes

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dc.contributor.author Huseynova, Mansura
dc.contributor.author Medjidov, Ajdar
dc.contributor.author Taslimi, Parham
dc.contributor.author Aliyeva, Mahizar
dc.date.accessioned 2019-04-29T07:15:13Z
dc.date.available 2019-04-29T07:15:13Z
dc.date.issued 2019-03
dc.identifier.uri http://hdl.handle.net/11772/1115
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0045206818309441
dc.description.abstract A new coordination polymer Zn(II) with thiosemicarbazone glyoxalic acid H(2)GAT was obtained in this study. According to the X-ray diffraction data, the coordination of the Zn(II) ion is carried out by one sulfur atom, in the thiol form, one nitrogen atom of the azomethine group and two oxygen atoms of the carboxylate groups, one of which belongs to neighbouring complex molecule. The oxygen atom of the water molecule completes Zn(II) ion environment to a distorted square-pyramidal structure. The binding of the monomer complex into polimer occurs through the bridge oxygen atom of carboxylate group. This complex is effective inhibitor of the alpha-glycosidase, butyrylcholinesterase (BChE), cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase enzymes (AChE) enzymes with Ki values of 1.45 +/- 0.23 mu M for hCA I, 2.04 +/- 0.11 mu M for hCA II, 3.47 +/- 0.88 mu M for alpha-glycosidase, 0.47 +/- 0.10 mu M for BChE, and 0.58 +/- 0.13 mu M for AChE, respectively. en_US
dc.language.iso eng en_US
dc.publisher Bioorganic Chemistry en_US
dc.relation.isversionof 10.1016/j.bioorg.2018.10.012 en_US
dc.relation.isversionof 10.1016/j.bioorg.2018.10.012
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Thiosemicarbazones en_US
dc.subject Zn-complex en_US
dc.subject Crystal structure en_US
dc.subject Antidiabetic en_US
dc.subject Anticholinergics en_US
dc.subject Enzyme inhibition en_US
dc.title Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes en_US
dc.type article en_US
dc.relation.journal Bioorganic Chemistry en_US
dc.contributor.department Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü en_US
dc.identifier.volume 83 en_US
dc.identifier.startpage 55 en_US
dc.identifier.endpage 62 en_US


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