DSpace@Bartin

Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects

Show simple item record

dc.contributor.author Cetin, Adnan
dc.contributor.author Türkan, Fikret
dc.contributor.author Taslimi, Parham
dc.contributor.author Gulçin, İlhami
dc.date.accessioned 2019-04-29T08:31:14Z
dc.date.available 2019-04-29T08:31:14Z
dc.date.issued 2019-03
dc.identifier.uri http://hdl.handle.net/11772/1129
dc.description.abstract Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K-i values in the range of 447.28 to 1004.65 nM for hCA I, 309.44 to 935.93 nM for hCA II, and 0.28 to 4.01 nM for AChE, respectively. Novel substituted thiophene derivatives can be good candidate drugs for the treatment of some diseases like neurological disorders, epilepsy, glaucoma, gastric and duodenal ulcers, mountain sickness, or osteoporosis as carbonic anhydrase isozymes inhibitors, and for the treatment of Alzheimer's and Parkinson's diseases as acetylcholinesterase inhibitors. en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.relation.isversionof 10.1002/jbt.22261 en_US
dc.rights info:eu-repo/semantics/restrictedAccess en_US
dc.subject Acetylcholinesterase en_US
dc.subject Carbonic anhydrase en_US
dc.subject Enzyme inhibition en_US
dc.subject Synthesis en_US
dc.subject Thiophene en_US
dc.title Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects en_US
dc.type article en_US
dc.relation.journal Journal of Biochemical and Molecular Toxicology en_US
dc.contributor.department Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü en_US
dc.identifier.volume 33 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage e22261 en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record




Search DSpace


Advanced Search

Browse

My Account

Statistics