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Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials

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dc.contributor.author Genç Bilgiçli, Hayriye
dc.contributor.author Kestane, Ali
dc.contributor.author Taslimi, Parham
dc.contributor.author Karabay, Oguz
dc.contributor.author Bytyqi-Damoni, Arlinda
dc.contributor.author Zengin, Mustafa
dc.contributor.author Gulçin, İlhami
dc.date.accessioned 2019-04-29T08:41:42Z
dc.date.available 2019-04-29T08:41:42Z
dc.date.issued 2019-04-16
dc.identifier.other https://doi.org/10.1016/j.bioorg.2019.102931
dc.identifier.uri http://hdl.handle.net/11772/1133
dc.description.abstract Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with Ki values in the range of 0.80 ± 0.24–3.52 ± 1.01 µM for hCA I, 1.08 ± 0.15–3.64 ± 0.92 µM for hCA II, 5.18 ± 0.84–12.46 ± 2.08 µM for α-glycosidase, and 11.33 ± 2.83–32.81 ± 9.73 µM for AChE, respectively en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.isversionof 10.1016/j.bioorg.2019.102931 en_US
dc.rights info:eu-repo/semantics/restrictedAccess en_US
dc.subject Eugenol en_US
dc.subject Antibacterial effects en_US
dc.subject α-glycosidase en_US
dc.subject Carbonic anhydrase en_US
dc.subject Acetylcholinesterase en_US
dc.subject Enzyme inhibition en_US
dc.title Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials en_US
dc.type article en_US
dc.relation.journal Bioorganic Chemistry en_US
dc.contributor.department Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü en_US
dc.identifier.volume 88 en_US


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