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Synthesis, characterization, molecular docking, and biological activities of novel pyrazoline derivatives

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dc.contributor.author Turkan, Fikret
dc.contributor.author Cetin, Adnan
dc.contributor.author Taslimi, Parham
dc.contributor.author HKaraman, alide S.
dc.contributor.author Gulçin, İlhami
dc.date.accessioned 2019-04-29T08:47:55Z
dc.date.available 2019-04-29T08:47:55Z
dc.date.issued 2019
dc.identifier.uri http://hdl.handle.net/11772/1134
dc.description.abstract In this study, synthesis of ethyl 2‐((4‐bromophenyl)diazenyl)‐3‐oxo‐phenylpropanoate 1 was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as well as various hydrazines. The obtained yields of the synthesized compounds were moderate (40‒70%) and these compounds were confirmed by spectral data. These novel pyrazoline derivatives were effective inhibitor compounds of the human carbonic anhydrase I and II isozymes (hCAs I and II) and of the acetylcholinesterase (AChE) enzyme, with Ki values in the range of 17.4–40.7 nM for hCA I, 16.1–55.2 nM for hCA II, and 48.2–84.1 nM for AChE. In silico studies were performed on the compounds inhibiting hCA I, hCA II, and AChE receptors. On the basis of the findings, the inhibition profile of the new pyrazoline compounds at the receptors was determined. en_US
dc.language.iso eng en_US
dc.publisher Wiley en_US
dc.relation.isversionof 10.1002/ardp.201800359 en_US
dc.rights info:eu-repo/semantics/restrictedAccess en_US
dc.subject pyrazoline en_US
dc.subject Acetylcholinesterase en_US
dc.subject Enzyme inhibition en_US
dc.subject Human carbonic anhydrase en_US
dc.subject In silico study en_US
dc.subject Induced fit docking en_US
dc.title Synthesis, characterization, molecular docking, and biological activities of novel pyrazoline derivatives en_US
dc.type article en_US
dc.relation.journal Archiv der Pharmazie en_US


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