Yazar "Taslimi, Parham" için Biyoteknoloji Bölümü listeleme
Toplam kayıt 76, listelenen: 1-20
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Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties
Güzel, Emre; Koçyiğit, Ümit M.; Arslan, Barış S.; Ataş, Mehmet; Taslimi, Parham; Gökalp, Faik; Nebioğlu, Mehmet; Şişman, İlkay; Gulçin, İlhami (Wiley, 2019-02)The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ... -
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
Gulçin, İlhami; Taslimi, Parham; Aygün, Ayşenur; Sadeghian, Nastaran; Bastem, Enes; Kufrevioglu, Omer Irfan; Turkan, Fikret; Şen, Fatih (Elsevier, 2018-11)The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity column chromatography. Also, alpha-amylase from porcine pancreas and alpha-glycosidase from Saccharomyces cerevisiae were used ... -
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Demir, Yeliz; Taslimi, Parham; Ozaslan, Muhammet Serhat; Oztaskin, Necla; Çetinkaya, Yasin; Gulçin, İlhami; Beydemir, Şükrü; Goksu, Suleyman (Wiley, 2018-12)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Antioxidant activity of the aqueous extract of iris taochia and identification of its chemical constituents
Askin, H.; Yilmaz, B.; Gulcin, I.; Taslimi, Parham; Bakirci, S.; Yildiz, M.; Kandemir, N. (Indian Journal of Pharmaceutical Sciences, 2018-09)In this study, phytochemical components and antioxidant capacity of extracts obtained from Iris taochia plant, which is endemic to Caucasus, were investigated. Fifteen new compounds were detected and identified using a ... -
Antioxidant activity, acetylcholinesterase, and carbonic anhydrase inhibitory properties of novel ureas derived from phenethylamines
Kadir, Aksu; Bunyamin, Ozgeris; Taslimi, Parham; Ali, Naderi; Ilhami, Gulcin; Suleyman, Goksu (Wiley, 2016-12)A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activities and ... -
Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives
Oztaskin, Necla; Cetinkaya, Yasin; Taslimi, Parham; Goksu, Suleyman; Gulcin, Ilhami (Elsevier, 2015-06)In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions ... -
Antioxidant and anticholinergic properties of olivetol
Taslimi, Parham (Wiley, 2018-06)Olivetol is a pioneer in diverse syntheses of tetrahydrocannabinol. It is produced by a type of insects, which is used as a pheromone, antiseptic, or repellent agent. In this study, we evaluated the antioxidant properties ... -
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
Kocyigit, Umit M.; Taslimi, Parham; Gulçin, İlhami (Wiley, 2018-08)In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ... -
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia
Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Oztaskin, Necla; Maraş, Ahmet; Gulçin, İlhami; Beydemir, Sukru; Goksu, Suleyman (Elsevier, 2018-11)Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ... -
The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach
Caglayan, Cuneyt; Demir, Yeliz; Kucukler, Sefa; Taslimi, Parham; Kandemir, Fatih Mehmet; Gulçin, İlhami (Wiley, 2019-02)In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 ... -
The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats
Turkan, Fikret; Huyut, Zubeyir; Taslimi, Parham; Gulcin, Ilhami (Taylor & Francis, 2019-01-01)In our study, it was aimed to investigate the effects of cefazolin, cefuroxime, and cefoperazon injected to rats on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme activities in the heart, brain, eye, ... -
The effects of some bromophenols on human carbonic anhydrase isoenzymes
Taslimi, Parham; Gulcin, Ilhami; Oztaskin, Necla; Cetinkaya, Yasin; Goksu, Suleyman; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016)Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to ... -
The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats
Umit Muhammet, Kocyigit,; Taslimi, Parham; Fatih, Gurses; Sinan, Soylu; Sevgi Durna, Dastan; Ilhami, Gulcin (Wiley, 2018-03)The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For ... -
Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes
Umit M., Kocyigit; Taslimi, Parham; Hayreddin, Gezegen; Ilhami, Gulcin; Mustafa, Ceylan (Wiley, 2017-09)Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ... -
The first synthesis and antioxidant and anticholinergic activities of 1-(4,5-dihydroxybenzyl)pyrrolidin-2-one derivative bromophenols including natural products
Mohsen, Rezai; Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Turkish Journal of Chemistry, 2018)We report herein the first synthesis of biologically active natural bromophenols, namely 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)pyrrolidin-2-one (2), 2RS-1- (2 ,3-dibromo-4 ,5-dihydroxybenz yl)-5-oxopyrrolidine-2-carboxylic ... -
The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes
Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Elsevier, 2017-06)The first synthesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl) but-3-en-2-one (1), (E)-4-(2-bromo-4,5-dihy droxyphenyl) but-3-en-2-one (2), and (E)-4-(2,3-dibromo-4,5-dihydroxyphenyl) but-3-en-2-one (3) was realized as natural ... -
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
Bayrak, Cetin; Taslimi, Parham; Karaman, Halide Sedef; Gulcin, Ilhami; Menzek, Abdullah (Bioorganic Chemistry, 2019-04)Starting from vanillin, known four benzyl bromides with Br were synthesized. The first synthesis of natural product 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (2) and 3,4,6-tribromo-5-((methylsulfonyl) ... -
The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives
Taslimi, Parham; Gulcin, Ilhami; Ozgeris, Bunyamin; Goksu, Suleyman; Tumer, Ferhan; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016-01)Carbonic anhydrases (CAs, EC 4.2.1.1) had six genetically distinct families described to date in various organisms. There are 16 known CA isoforms in humans. Human CA isoenzymes I and II (hCA I and hCA II) are ubiquitous ... -
Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition
Yiğit, Beyhan; Kaya, Ruya; Taslimi, Parham; Işık, Yılmaz; Karaman, Muhammet; Yiğit, Murat; Özdemir, İsmail; Gulçin, İlhami (Journal Of Molecular Structure, 2019-03-05)A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N'-dialkylethane-1,2-diamines and HC(OEt)(3) in the presence of NH4Cl. These ... -
The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study
Taslimi, Parham; Cuneyt, Caglayan; Ilhami, Gulcin (Wiley, 2017-12)Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, ...