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dc.contributor.authorKorkmaz, Nesrin
dc.contributor.authorKaradağ, Ahmet
dc.date.accessioned2019-04-19T06:40:33Z
dc.date.available2019-04-19T06:40:33Z
dc.date.issued2015-02-16
dc.identifier.urihttp://hdl.handle.net/11772/1041
dc.description.abstractTwo novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag3 (CN)5]n (C1) and [Ni(bishydeten) Au2 (CN)4 ]n (C2), where edbea = [2,2′-(ethylenedioxy)bis(ethylamine)] and bishydeten = [(N ,N′-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines. The results show that both compounds and free anions, [Ag(CN)2 ]− and [Au(CN)2 ]−, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested. The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free anions decreased to safe levels in C1 and C2. In conclusion, the results show that these novel compounds possess anticancer activitiesen_US
dc.description.sponsorshipTUBITAK through project no. 112T696en_US
dc.language.isoengen_US
dc.publisherTÜBİTAKen_US
dc.relation.isversionof10.3906/kim-1412-13en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDicyanidoargentateen_US
dc.subjectDicyanidoaurateen_US
dc.subjectCoordination polymersen_US
dc.subjectAnticancer activityen_US
dc.subjectApoptosisen_US
dc.titleTwo new coordination polymers containing dicyanidoargentate(I) and dicyanidoaurate(I): synthesis and characterization, and a detailed in vitro investigation of their anticancer activities on some cancer cell linesen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume2015en_US
dc.identifier.issue39en_US
dc.identifier.startpage532en_US
dc.identifier.endpage549en_US


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