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dc.contributor.authorKorkmaz, Nesrin
dc.contributor.authorKaradağ, Ahmet
dc.date.accessioned2019-04-25T06:54:42Z
dc.date.available2019-04-25T06:54:42Z
dc.date.issued2017-01-01
dc.identifier.urihttp://hdl.handle.net/11772/1077
dc.description.abstractFour compounds -two (2 and 3) completely new- of composition [Ni(edbea)Ag3(CN)5] (1), [Cu(edbea)Ag2(CN)4]·H2O (2), [Cd(edbea)Ag3(CN)5]·H2O (3) and [Cd(edbea)2] [Ag(CN)2]2·H2O (4) {edbea; 2,2′-(ethylenedioxy)bis (ethylamine)}, were synthesized and characterized using elemental, FT-IR, X-Ray (4), thermal, variable temperature magnetic measurement (1 and 2) and biological techniques. The DNA/BSA binding affinities of 2 and 3 were evaluated by UV–Vis spectrophotometric titrations, ethidium bromide exchange experiments and electrophoretic mobility measurements. Compounds 1 and 4 have previously been characterized and shown to reduce the proliferation and migration of tumor cells. For the sake of clarity, 1 precise mechanism of action on microbial organisms and temperature magnetic measurement were determined. The crystallographic analyses showed that 4 was built up of [Cd(edbea)2]II cations and [Ag2(CN)4]II anions. Complexes demonstrated a remarkable antibacterial (1–4), antifungal (1–4) and antiproliferative activities (2 and 3) to ten human bacterial pathogens, four plant pathogenic fungi or three tumor cells (HeLa, HT29, and C6), respectively. Therefore, our results strongly confirm that cell proliferation, cell morphology, Bcl-2, P53 changes and apoptosis can be related to the pharmacological effects of the complexes as suitable candidate for clinical trials.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.saa.2016.10.035en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectapoptosisen_US
dc.subjectantifungal activityen_US
dc.subjectanticancer activityen_US
dc.subjectantimicrobial activityen_US
dc.subjectdicyanidoargentat(I)en_US
dc.subject2,2'-(ethylenedioxy)bis(ethylamine)en_US
dc.titleNew bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinitiesen_US
dc.typearticleen_US
dc.relation.journalSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.contributor.authorID0000-0002-7896-1042en_US
dc.identifier.volume173en_US
dc.identifier.issue2017en_US
dc.identifier.startpage1007en_US
dc.identifier.endpage1022en_US


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