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dc.contributor.authorÖkten, Salih
dc.contributor.authorEkiz, Makbule
dc.contributor.authorKoçyiğit, Ümit Muhammet
dc.contributor.authorTutar, Ahmet
dc.contributor.authorÇelik, İsmail
dc.contributor.authorAkkurt, Mehmet
dc.contributor.authorGökalp, Faik
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2019-04-29T08:39:20Z
dc.date.available2019-04-29T08:39:20Z
dc.date.issued2019-01-05
dc.identifier.urihttp://hdl.handle.net/11772/1132
dc.description.abstractThe six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, elemental analysis and XRD investigations. The silyl substituted novel tacrine derivatives (9-11) were investigated as cholinesterase inhibitors and defined the relative role of AChE (Acetylcholinesterase) versus BChE (Butyrylcholinesterase) inhibition. Novel substituted tacrine derivatives are known as important inhibitors of Carbonic anhydrase (CA) isoenzymes I, and II (hCA I and II), therefore, the synthesized compounds (9-11) were investigated for inhibitory effects on the both CA isoenzymes. Additionally, we evaluated four different enzymes, which were inhibited in the very low nanomolar (nM) range by these compounds. According to the present studies, for AChE, BChE, hCA I and II, the ranges of results are recorded as 30.26 +/- 6.71-117.54 +/- 42.22 nM, 22.45 +/- 5.81-77.41 +/- 4.02 nM, 57.28 +/- 22.16-213.41 +/- 82.75 nM and 46.95 +/- 11.32-274.94 +/- 62.15 nM, respectively. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.molstruc.2018.08.063en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectSilyl tacrineen_US
dc.subjectDeprotonation of amineen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitoren_US
dc.titleSynthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitorsen_US
dc.typearticleen_US
dc.relation.journalJournal Of Molecular Structureen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume1175en_US
dc.identifier.startpage906en_US
dc.identifier.endpage915en_US


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