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dc.contributor.authorTimur, İrfan
dc.contributor.authorKocyigit, Ümit M.
dc.contributor.authorDastan, Taner
dc.contributor.authorSandal, Süleyman
dc.contributor.authorCeribası, Ali Osman
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcin, İlhami
dc.contributor.authorKoparir, Metin
dc.contributor.authorKaratepe, Mustafa
dc.contributor.authorÇiftç, Mehmet
dc.date.accessioned2019-04-30T07:01:25Z
dc.date.available2019-04-30T07:01:25Z
dc.date.issued2019-01
dc.identifier.urihttp://hdl.handle.net/11772/1139
dc.description.abstractThe 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a series of triazole compounds (M1-M10) were evaluated for some biological activities. In vitro qualifications of these compounds on acetylcholinesterase (AChE) and human carbonic anhydrase enzyme activities were performed. Also, their antitumoral activities in human colon cancer (HT29) cell line cultures were examined. In addition, colon cancer experimentation was induced in rats by an in vivo method, and the in vivo anticancer effects of triazole derivatives were investigated. Also, the effects of these derivatives in levels of antioxidant vitamin A, vitamin E, and MDA were studied in rat liver and blood samples. Most of the compounds were found to exhibit significant antioxidant and antitumoral activities. All the compounds had cytotoxic activities on HT29 cell lines with their IC50 values lower than 10 mu M concentrations. The low IC50 values of the compounds are M1 (3.88 mu M), M2 (2.18 mu M), M3 (4.2 mu M), M4 (2.58 mu M), M5 (2.88 mu M), M6 (2.37 mu M), M7 (3.49 mu M), M8 (4.01 mu M), M9 (8.90 mu M), and M10 (3.12 mu M).en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.22239en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectMDAen_US
dc.subjectAntitumoural activityen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectTriazoleen_US
dc.titleIn vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4‐dihydro‐3H‐1,2, 4‐triazole‐3‐thiones—Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profilesen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume33en_US
dc.identifier.issue1en_US
dc.identifier.startpagee22239en_US


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