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dc.contributor.authorYiğit, Beyhan
dc.contributor.authorYiğit, Murat
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGök, Yetkin
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2019-05-06T13:50:36Z
dc.date.available2019-05-06T13:50:36Z
dc.date.issued2018-09
dc.identifier.urihttp://hdl.handle.net/11772/1159
dc.description.abstractThree series of symmetrical Schiff bases were synthesized from 1,2-diaminoethane, 1,3-diaminopropane and 1,4-diaminobutane and substituted benzaldehydes, and reduced by sodium borohydride to the corresponding benzylic diamines 4-6. All of the compounds obtained were characterized using elemental analysis, FT-IR, H-1 NMR, and C-13 NMR spectroscopy. The enzyme inhibitory properties of these compounds were tested and the influence of the alkane chain length and the substituents on the phenyl group on the enzyme inhibition activity were examined. The novel Schiff bases and their amine derivatives (1a-d, 2a-d, 3b-d, 4a-c, 5a-c, 6a, 6c, 6d) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) with K-i values in the range of 159.43 +/- 30.03 to 563.73 +/- 115.30nM for hCA I, 104.88 +/- 18.44 to 524.32 +/- 95.03nM for hCA II, and 3.95 +/- 0.74 to 30.83 +/- 6.81nM for AChE.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ardp.201800146en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subject1,2-diaminoethaneen_US
dc.subject1,3-diaminopropaneen_US
dc.subjectSchiff basesen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSchiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitorsen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume351en_US
dc.identifier.issue9en_US
dc.identifier.startpagee1800146en_US


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