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dc.contributor.authorYakup, Sari
dc.contributor.authorAydin, Aktas
dc.contributor.authorTaslimi, Parham
dc.contributor.authorYetkin, Gok,
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-17T06:38:34Z
dc.date.available2019-05-17T06:38:34Z
dc.date.issued2018-01
dc.identifier.urihttp://hdl.handle.net/11772/1183
dc.description.abstractThe novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted NHC precursors have been characterized by using H-1 NMR, C-13 NMR, FTIR spectroscopy, and elemental analysis techniques. They were tested for the inhibition of AChE and hCA enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 351.0-1269.9 nM against hCA I, 346.6-1193.1 nM against hCA II, and 19.0-76.3 nM against AChE. On the other hand, acetazolamide, a clinically used molecule, utilized as CA inhibitor, obtained a K-i value of 1246.7 nM against hCA I and 1407.6 nM against hCA II. Additionally, tacrine inhibited AChE and obtained a K-i value of 174.6 nM.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.22009en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectN-heterocyclic carbene precursorsen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectBenzimidazoleen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectMetal chelatingen_US
dc.titleNovel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymesen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume32en_US
dc.identifier.issue1en_US
dc.identifier.startpagee22009en_US


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