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dc.contributor.authorTaslimi, Parham
dc.contributor.authorCuneyt, Caglayan
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-17T06:41:49Z
dc.date.available2019-05-17T06:41:49Z
dc.date.issued2017-12
dc.identifier.urihttp://hdl.handle.net/11772/1184
dc.description.abstractNatural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), -glucosidase (-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). These phenolic compounds were tested for the inhibition of -glycosidase, hCA I, hCA II, AChE, and BChE enzymes and demonstrated efficient inhibition profiles with K-i values in the range of 3.70 +/- 0.92-79.66 +/- 20.81nM against hCA I, 2.98 +/- 0.33-84.88 +/- 40.32nM against hCA II, 4.93 +/- 2.01-593.60 +/- 134.74nM against -Gly, 0.52 +/- 0.18-46.80 +/- 17.15nM against AChE, and 1.25 +/- 0.22-32.08 +/- 2.68 against BChE.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.21995en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectPhenolic compoundsen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectGlycosidaseen_US
dc.titleThe impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic studyen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue12en_US
dc.identifier.startpagee21995en_US


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