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dc.contributor.authorEmin, Garibov
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAfsun, Sujayev
dc.contributor.authorZeynebe, Bingol
dc.contributor.authorSongul, Cetinkaya
dc.contributor.authorIlhami, Gulcin
dc.contributor.authorSukru, Beydemir
dc.contributor.authorVagif, Farzaliyev
dc.contributor.authorSaleh H., Alwasel
dc.contributor.authorClaudiu T., Supuran
dc.date.accessioned2019-05-17T06:46:21Z
dc.date.available2019-05-17T06:46:21Z
dc.date.issued2016-12
dc.identifier.urihttp://hdl.handle.net/11772/1185
dc.description.abstractA series of tetrahydropyrimidinethiones were synthesized from thiourea, -diketones and aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde, salicylaldehyde and benzaldehyde. These cyclic thioureas showed good inhibitory action against acetylcholine esterase (AChE), butyrylcholine esterase (BChE), and human (h) carbonic anhydrase (CA) isoforms I and II. AChE and BChE inhibitions were in the range of 6.11-16.13 and 6.76-15.68nM, respectively. hCA I and II were effectively inhibited by these compounds, with K-i values in the range of 47.40-76.06nM for hCA I, and of 30.63-76.06nM for hCA II, respectively. The antioxidant activity of the cyclic thioureas was investigated by using different in vitro antioxidant assays, including 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Cu(2+)and Fe(3+)reducing, and Fe(2+)chelating activities.en_US
dc.language.isoengen_US
dc.publisherInformaen_US
dc.relation.isversionof10.1080/14756366.2016.1198901en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAntioxidant activityen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activitiesen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US


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