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dc.contributor.authorUmit M., Kocyigit
dc.contributor.authorTaslimi, Parham
dc.contributor.authorHayreddin, Gezegen
dc.contributor.authorIlhami, Gulcin
dc.contributor.authorMustafa, Ceylan
dc.date.accessioned2019-05-17T08:15:59Z
dc.date.available2019-05-17T08:15:59Z
dc.date.issued2017-09
dc.identifier.urihttp://hdl.handle.net/11772/1196
dc.description.abstractCarbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ailments such as dementia and vascular dementia with Lewy bodies reduce cholinergic activity in the important areas involved in cognition and memory. Prevalent drugs for the symptomatic therapy of dementia are significant in increasing the associated cholinergic deficiency by inhibiting acetylcholinesterase (AChE). These six-membered carbocycles showed nice inhibitory action against AChE and human carbonic anhydrase (hCA) II and I isoforms. The hCA I, II, and AChE were efficiently inhibited by these molecules, with K-i values in the range of 6.70-35.85nM for hCA I, 18.77-60.84nM for hCA II, and 0.74-4.60 for AChE, respectively.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.21938en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectDomino reactionsen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPentasubstituted cyclohexanolen_US
dc.titleEvaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanesen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue9en_US
dc.identifier.startpagee21938en_US


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