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dc.contributor.authorIlhami, Gulcin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorDastan, Taner
dc.contributor.authorKoçyiğit, Ümit M.
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorKılıçkaya, Pakize Cantürk
dc.contributor.authorÇevik, Özge
dc.contributor.authorKoparır, Metin
dc.contributor.authorOrek, Cahit
dc.contributor.authorÇetin, Ahmet
dc.date.accessioned2019-05-17T08:36:23Z
dc.date.available2019-05-17T08:36:23Z
dc.date.issued2017-11
dc.identifier.urihttp://hdl.handle.net/11772/1201
dc.description.abstractThe aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel eight bis(-aminoalkyl)phosphinic acid derivatives (4a-h) as a result of array of reactions, compounds were evaluated by cytotoxic effects in vitro on human breast cancer (MCF-7) and normal endothelial (HUVEC) cell lines. All phosphinic acid derivatives were effective for cytotoxicity on both MCF-7 and HUVEC lines, while 4c, 4e, and 4f compounds were found significantly more effective. For the evaluation of antitumor properties of compounds in a highly sensitive method, their effects on inhibiting topoisomerases I and II were investigated. Also, some of the bis(-aminoalkyl)phosphinic acid derivatives (4a, 4e-h) showed nice inhibitory action against acetylcholinesterase and human carbonic anhydrase isoforms I and II.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.21971en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCytotoxicityen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectPhosphinic aciden_US
dc.subjectTopoisomeraseen_US
dc.titleInvestigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast canceren_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume31en_US
dc.identifier.issue11en_US
dc.identifier.startpagee21971en_US


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