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dc.contributor.authorOztaskin, Necla
dc.contributor.authorCetinkaya, Yasin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGoksu, Suleyman
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2019-06-13T06:35:15Z
dc.date.available2019-06-13T06:35:15Z
dc.date.issued2015-06
dc.identifier.urihttp://hdl.handle.net/11772/1386
dc.description.abstractIn this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions of benzoic acids with substituted benzenes. One of the bromodiarylmethanone was synthesized from the bromination of diarylmethanone with molecular bromine. All diarylmethanones were converted into their bromophenol derivatives with BBr3. The antioxidant activities of all synthesized compounds were elucidated by using various bioanalytical assays. Radical scavenging activities of compounds 10-24 were evaluated by means of DPPH center dot and ABTS(center dot+) scavenging activities. In addition, reducing ability of 10-24 were determined by Fe3+, Cu2+, and [Fe3+-(TPTZ)(2)](3) reducing activities. alpha-Tocopherol, trolox, BHA, and BHT were used as positive antioxidant and radical scavenger molecules. On the other hand, IC50 values were calculated for DPPH center dot, ABTS(center dot+) scavenging, and AChE inhibition effects of novel compounds. The results obtained from the current studies clearly show that novel bromophenol derivatives 20-24 have considerable antioxidant, antiradical, and AChE inhibition effects. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bioorg.2015.04.006en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectAntioxidant activityen_US
dc.subjectBromophenolsen_US
dc.subjectDiarylmethanonesen_US
dc.subjectDemethylationen_US
dc.subjectEnzyme inhibitionen_US
dc.titleAntioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivativesen_US
dc.typearticleen_US
dc.relation.journalBioorganic Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume60en_US
dc.identifier.startpage49en_US
dc.identifier.endpage57en_US


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