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      Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes 

      Parham, Taslimi; Ilhami, Gulcin (Wiley, 2017-10)
      -Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase ...
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      Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep 

      Kocyigit, Umit M.; Taslimi, Parham; Gulçin, İlhami (Wiley, 2018-08)
      In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ...
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      Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base 

      Parham, Taslimi; Sabiya, Osmanova; Ilhami, Gulcin; Sabira, Sardarova; Vagif, Farzaliyev; Afsun, Sujayev; Ruya, Kaya; Fatma, Koc; Sukru, Beydemir; Saleh H., Alwasel; Omer Irfan, Kufrevioglu (Wiley, 2017-09)
      Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ...
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      The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats 

      Umit Muhammet, Kocyigit,; Taslimi, Parham; Fatih, Gurses; Sinan, Soylu; Sevgi Durna, Dastan; Ilhami, Gulcin (Wiley, 2018-03)
      The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For ...
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      Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes 

      Umit M., Kocyigit; Taslimi, Parham; Hayreddin, Gezegen; Ilhami, Gulcin; Mustafa, Ceylan (Wiley, 2017-09)
      Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ...
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      The impact of some natural phenolic compounds on carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and -glycosidase enzymes: An antidiabetic, anticholinergic, and antiepileptic study 

      Taslimi, Parham; Cuneyt, Caglayan; Ilhami, Gulcin (Wiley, 2017-12)
      Natural products from food and plant sources have been used for medicinal usage for ages. Also, natural products with therapeutic significance are compounds derived from animals, plants, or any microorganism. In this study, ...
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      In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4‐dihydro‐3H‐1,2, 4‐triazole‐3‐thiones—Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles 

      Timur, İrfan; Kocyigit, Ümit M.; Dastan, Taner; Sandal, Süleyman; Ceribası, Ali Osman; Taslimi, Parham; Gulcin, İlhami; Koparir, Metin; Karatepe, Mustafa; Çiftç, Mehmet (Wiley, 2019-01)
      The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a ...
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      The in vivo effects of cefazolin, cefuroxime, and cefoperazon on the carbonic anhydrase in different rat tissues 

      Fikret, Turkan; Zubeyir, Huyut; Parham, Taslimi; Ilhami, Gulcin (Wiley, 2018-03)
      In this paper, the in vivo effects of some antibiotics including cefazolin, cefuroxime, and cefoperazon, on the activity of the carbonic anhydrase enzyme (CA) in heart, brain, eye, liver, and kidney tissues of rats were ...
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      Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats 

      Ilhami, Gulcin,; Taslimi, Parham; Koçyiğit, Ümit M.; Taşkıran, Ahmet Şevki; Yokus, Ahmet; Temel, Yusuf (Wiley, 2017-11)
      The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase ...
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      The Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey 

      Umit M., Kocyigit; Sevgi Durna, Dastan; Taslimi, Parham; Taner, Dastan; Ilhami, Gulcin (Wiley, 2018-01)
      In this study, carbonic anhydrase (CA) enzyme was purified and characterized from blood samples of Kangal Akkaraman sheep and inhibitory properties on certain antibiotics were examined. CA purification was composed of ...
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      Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes 

      Atmaca, Ufuk; Yıldırım, Alper; Taslimi, Parham; Çelik, Seda Tuncel; Gülçin, İlhami; Supuran, Claudiu T.; Çelik, Murat (Gulcin, I; Celik, M, 2018-08)
      In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f). carbonyl sulfonamides (3h and i). and carbonyl sulfamates (4h and 4i), which were tested against two ...
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      Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer 

      Ilhami, Gulcin; Taslimi, Parham; Dastan, Taner; Koçyiğit, Ümit M.; Dastan, Sevgi Durna; Kılıçkaya, Pakize Cantürk; Çevik, Özge; Koparır, Metin; Orek, Cahit; Çetin, Ahmet (Wiley, 2017-11)
      The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ...
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      Novel amides of 1,1‐bis‐(carboxymethylthio)‐1‐arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties 

      Taslimi, Parham; Osmanova, Sabiya; Caglayan, Cuneyt; Turkan, Fikret; Sardarova, Sabira; Farzaliyev, Vagif; Sujayev, Afsun; Sadeghian, Nastaran; Gulçin, İlhami (Wiley, 2018-09)
      The thiolation reaction was carried out in a benzene solution at 80 degrees C and p-substituted ketones and mercaptoacetic acid in a molar ratio (1:4) of in the presence of a catalytic amount of toluene sulfonic acids. The ...
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      Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes 

      Yakup, Sari; Aydin, Aktas; Taslimi, Parham; Yetkin, Gok,; Ilhami, Gulcin (Wiley, 2018-01)
      The novel N-propylphthalimide-substituted and 4-vinylbenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by N-substituted benzimidazolium with aryl halides. The novel N-propylphthalimide-substituted ...
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      Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors 

      Taslimi, Parham; Akıncıoğlu, Hülya; İlhami, Gülçin (Wiley, 2017-11)
      In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase ...
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      Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects 

      Cetin, Adnan; Türkan, Fikret; Taslimi, Parham; Gulçin, İlhami (Wiley, 2019-03)
      Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene ...
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      Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivatives 

      Taslimi, Parham; Cuneyt, Caglayan; Vagif, Farzaliyev; Oruj, Nabiyev; Afsun, Sujayev; Fikret, Turkan; Ruya, Kaya; Ilhami, Gulcin (Wiley, 2018-04)
      During this investigation, N,N'-bis-azidomethylamines, N,N'-bis-cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, ...
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      Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities 

      Parham, Taslimi; Afsun, Sujayev; Fikret, Turkan; Emin, Garibov; Zubeyir, Huyut; Vagif, Farzaliyev; Sevgi, Mamedova; Ilhami, Gulcin (Wiley, 2018-02)
      The conversion reactions of pyrimidine-thiones with nucleophilic reagent were studied during this scientific research. For this purpose, new compounds were synthesized by the interaction between 1,2-epoxy propane, 1,2-epoxy ...
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      Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles 

      Taslimi, Parham; Afsun, Sujayev; Emin, Garibov; Nazar, Nazarov; Zubeyir, Huyut; Saleh H., Alwasel; Ilhami, Gulcin (Wiley, 2017-07)
      In the presence of trifluoracetic acid (TFAA), an efficient method for the synthesis of tetra(hexa)hydropyrimidinethione-carboxylates has been used on the basis of three-component condensation of thiourea with its different ...
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      Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles 

      Nilufer, Bulut; Umit M., Kocyigit; Ibrahim H., Gecibesler; Taner, Dastan; Huseyin, Karci; Taslimi, Parham; Sevgi Durna, Dastan; Ilhami, Gulcin; Ahmet, Cetin (Wiley, 2018-01)
      Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic ...

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