Bartın Üniversitesi Araştırma ve Akademik Performans Sistemi
DSpace@Bartın, Bartın Üniversitesi’nin bilimsel araştırma ve akademik performansını izleme, analiz etme ve raporlama süreçlerini tek çatı altında buluşturan bütünleşik bilgi sistemidir.
İndekslere Göre Dağılım
Yıllara Göre Dağılım
Türlere Göre Dağılım
Güncel Gönderiler
Öğe Türü: Yayın , Effect of 3200 MHz Radiofrequency Fields on MCF-7 and L929 Cell Lines(Sakarya University, 2026) Eraslan, Sinem Oruç; Günay, Sevilay; Ateş, Kayhan; Erden, Yavuz; Aral, Bahriye Sırav; Erden, Yavuz; Fen Fakültesi, Moleküler Biyoloji ve Genetik BölümüObjective: The use of technological devices emitting radio frequency fields(RFF) is increasing day by day. Nowadays, low-frequency RFF has begun to be used in cancer treatment as a non-invasive method. However, the time-dependent effects of high-frequency RFF on healthy and cancer cells are not yet clear. This study aims to examine the time-dependent effects of 3200MHz RFF on human breast cancer (MCF-7) and healthy mouse fibroblast (L929) cell lines. Methods: MCF-7 and L929 cells were cultured with DMEM medium. RFF exposures were applied at 29.55dBm power levels (with Efield level 14V/m). MCF-7 and L929 cell lines were exposed to 3200 MHz RFF for 4 hours. Cell viability levels were determined immediately after exposure and following a 2-hour post-exposure incubation period. Results: Immediately after 4 hours of 3200 MHz RFF exposure, cell viability decreased significantly by 12% in MCF-7 cells, with a further 15% decrease observed after a 2-hour post-exposure period. In contrast, the L929 cell line exhibited a significant increase in viability, with levels rising by 27% immediately after exposure and by 16% following the 2-hour post-exposure period(p<0.0001). Conclusions: The results of this study suggest that 3200MHz RFF exposure has a significant effect on the viability levels of cancer cells and that 3200MHz RFF can create the effect that low-frequency fields currently used as a non-invasive method have with a significant temperature increase, without a temperature increase. It is also effective in increasing healthy fibroblast cells, suggesting that it can be used as an alternative method to wound healing and cell renewal treatments.Öğe Türü: Yayın , Digital interventions for fear of childbirth and related maternal outcomes: a systematic review and meta-analysis of randomized controlled trials(Churchill Livingstone, 2026) Temiz, Mehtap; Metin, Zehra Gök; Temiz, Mehtap; Sağlık Bilimleri Fakültesi, Hemşirelik BölümüObjective: To evaluate the effectiveness of digital interventions for reducing antenatal fear of childbirth and improving related maternal outcomes. Design: Systematic review and meta-analysis of randomized controlled trials. Data sources: PubMed, Scopus, Web of Science, the Cochrane Library, and Google Scholar were searched for studies published from January 2015 through December 2025; reference lists were also screened. Eligibility criteria: Randomized trials of structured digital behavioural, educational, or psychological interventions initiated during pregnancy for women aged 18 years or older were eligible. Intrapartum-only distraction interventions were excluded. Methods: Two reviewers independently screened studies, re-verified outcome-level data against full reports, assessed risk of bias using RoB 2, and graded certainty using GRADE. Hedges' g was pooled with REML random-effects models, Hartung-Knapp confidence intervals, and prediction intervals. Outcomes unsuitable for pooling were synthesized using SWiM. Results: Fourteen independent trials (1563 randomized participants; 1334 in the primary endpoint analysis) were included. Digital interventions were associated with lower antenatal fear of childbirth (g = -1.54, 95% CI -2.66 to -0.43; I2 = 96.8%; 95% prediction interval -5.81 to 2.72; very-low-certainty evidence). Childbirth self-efficacy was not significantly improved (g = 2.64, 95% CI -1.27 to 6.55; I2 = 97.1%; very-low-certainty evidence). Early postpartum fear favoured intervention in an exploratory analysis (g = -1.81, 95% CI -3.58 to -0.03; I2 = 97.3%; prediction interval -6.73 to 3.12). Depression, labour pain, anxiety, childbirth experience, and obstetric outcomes were synthesized without meta-analysis because measures, timings, or constructs were not sufficiently comparable. Conclusions: The average estimate suggests that digital interventions may reduce antenatal fear of childbirth, but extreme heterogeneity, a prediction interval crossing the null, influential large effects, and very-low certainty preclude a universal effectiveness claim. Evidence for self-efficacy and other maternal outcomes remains inconclusive. Registration: PROSPERO CRD420251252742. ©Öğe Türü: Yayın , High-Resolution UAV-Derived Urban Radiation Environment Mapping Through Mean Radiant Temperature Simulation Using SOLWEIG(Springer Basel AG, 2026) Kaya, Efdal; Özel, Halil Barış; Ağca, Müge; Çetin, İlknur Zeren; Zeren, Dilek Birgül; Altunay, Rıza; Özel, Halil Barış; Orman Fakültesi, Orman Mühendisliği BölümüUrban areas are increasingly exposed to extreme heat conditions due to rapid urbanization, climate change, and the intensification of the Urban Heat Island (UHI) effect. Accurate characterization of the urban radiation environment is therefore essential for supporting climate-responsive urban planning and sustainable landscape design. This study presents a high-resolution microscale assessment of the spatial and temporal distribution of mean radiant temperature (Tmrt) in a representative urban district of Bal & ccedil;ova, & Idot;zmir, T & uuml;rkiye, using unmanned aerial vehicle (UAV)-derived spatial data and the Solar and LongWave Environmental Irradiance Geometry (SOLWEIG) model implemented within the Urban Multi-scale Environmental Predictor (UMEP) framework in QGIS. High-resolution Digital Surface Models (DSM) and Digital Elevation Models (DEM) were generated from UAV photogrammetry and integrated with hourly meteorological observations, including air temperature, relative humidity, and wind speed, obtained from the Turkish State Meteorological Service for 10 June 2023 Hourly meteorological observations corresponding to 10 June 2023 were obtained from the Turkish State Meteorological Service (TSMS). The SOLWEIG model was employed to simulate hourly mean radiant temperature, shadow distribution, wall characteristics, and sky view factor (SVF), enabling detailed evaluation of radiation exposure across a microscale urban environment. The simulation results demonstrate substantial spatial variability in mean radiant temperature associated with urban morphology. Areas characterized by taller buildings, greater shading intensity, and reduced sky exposure consistently exhibited lower Tmrt values throughout the daytime, whereas open paved surfaces with high sky visibility experienced considerably greater radiative heat loads. The generated shadow and SVF maps further reveal the dominant influence of building geometry and vegetation on modifying local radiation conditions. Rather than directly evaluating human thermal comfort indices such as Physiological Equivalent Temperature (PET) or Universal Thermal Climate Index (UTCI), this research focuses specifically on the radiative component governing outdoor thermal environments through high-resolution Tmrt modelling. The findings demonstrate that integrating UAV-derived three-dimensional urban morphology with physically based radiation modelling provides an effective framework for identifying localized heat exposure patterns and supporting evidence-based urban climate adaptation strategies. The proposed methodology offers a practical, open-source, and transferable workflow for microscale urban radiation assessment in climate-sensitive cities while providing valuable spatial information for future thermal comfort analyses and urban design applications.Öğe Türü: Yayın , Tutoring Model for Intelligent Tutoring Systems: Adaptive Instructional Scaffoldings Based on Experiences of the Learner Digital Twin(Springer Science + Business Media, 2026) Aydın, Furkan; Yurdugül, Halil; Aydın, Furkan; Fen Fakültesi, Bilgisayar Teknolojisi ve Bilişim Sistemleri BölümüThis study investigates the impact of scaffolding provided based on learners’ digital twins within Intelligent Tutoring Systems (ITS) on participants’ performance and instructional support behaviors. Employing a quasi-experimental design, the research involved 104 university learners who were divided into experimental and control groups. The experimental group utilized an adaptive ITS that identified digital twins to provide personalized scaffolding, while the control group used an adaptable ITS where learners chose their support types. Data were collected through pre-tests, post-tests, and interaction logs, focusing on the effects of the instructional supports provided by the two different systems on academic performance. Statistical analyses, including paired-sample t-tests and ANCOVA, indicated significant improvements in the experimental group’s academic performance, with effect sizes showing a higher impact compared to the control group. Additionally, the adaptive system led to reduced behaviors related to receiving instructional support, suggesting that learner digital twin–based scaffolding may support learning outcomes by reducing the burden of learner self-selection and providing system-guided instructional support.Öğe Türü: Yayın , Synthesis, Structural Analyses, Antimicrobial Activities, DNA Topoisomerase Inhibition, Cytotoxicity, and Genotoxicity Studies of Unsymmetrical Dispiro(N/N)Cyclotriphosphazenes(Wiley-Blackwell Publishing Ltd, 2026) Cemaloğlu, Reşit; İşcan, Özlem; Asmafiliz, Nuran; Tümer, Yasemin; Açık, Leyla; Kılıç, Zeynel; Sabah, Büşra Nur; Çelik, Süheyla Pınar; Hökelek, Tuncer; Foto, Fatma Zilifdar; Foto, Egemen; İşcan, Özlem; Rektörlüğe Bağlı Birimler, Proje ve Teknoloji Ofisi Genel KoordinatörlüğüIn this study, the synthesis, characterization, chiral properties, and bioactivities of partially and fully substituted unsymmetrical cis-(1a-4a, S1a, S3a, and S4a) and trans-(1a-4a)dispirocyclotriphosphazenes were investigated. All cis- and trans-dispirocyclotriphosphazenes are expected to exist as pseudomesoracemates and racemates, respectively. The single-crystal X-ray analysis of trans-1a proves that the compound exists as a racemic mixture (RR'/SS'). Moreover, cis-2a is a pseudomesoracemate, and the absolute configuration of one enantiomer was found to be SR'. 31P NMR spectra of cis/trans-2a recorded with the addition of (R)-(-)-1-(9’-anthryl)-2,2,2-trifluoroethanol (CSA) confirmed these findings. Furthermore, the antimicrobial activities, DNA interactions, topoisomerase I (Topo I) inhibitory properties, cytotoxic, genotoxic and mutagenic potentials of the dispirocyclotriphosphazenes have also been demonstrated. Compounds trans-2a, cis-3b, and trans-3b show lower MBC values against Klebsiella pneumoniae ATCC 13883 than ampicillin. Cis-2a and trans-3b (MBC = 78.1 µM) are as effective as the control ketoconazole against the yeasts Candida krusei and Candida tropicalis. Since selectivity indices ranged from 0.9 to 1.8, trans-3a, trans-3b, trans-4a, and trans-4b showed moderate cytotoxic effects against HT29 human cancer cells. DNA-binding and topoisomerase-inhibition assays indicate that these effects occur through DNA binding and alteration of the compounds' topology. Trans-3b showed the highest genotoxic effect against both cancer and healthy cells.
