Metal-containing Coordination Complexes (MCCs): Assessment of Biological Activity with Helicobacter pylori Caused Gastric Ulcer

Abstract

The ulcer is a vital disease that unfavorably affects human health globally. Helicobaster pylori, which causes ulcers and some stomach disorders, survives by using the urease enzyme. Metal coordination complexes (MCCs) are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several applications. In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)<inf>2</inf>Ag(CN)<inf>2</inf>][Ag(CN)<inf>2</inf>].H<inf>2</inf>O), and (C2), ([Ni(hydeten)<inf>2</inf>Ag(CN)<inf>2</inf>][Ag(CN)<inf>2</inf>], MCCs were analyzed by disk diffusion, broth dilution and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 values between 26.65±1.21 and 12.37±0.87 µM for urease. © 2025 Elsevier B.V., All rights reserved.