New dinuclear cyanido complexes with amine alcohol ligand: Synthesis, characterization and biotechnological application potential

Abstract

In this study, the cyanido complexes given by the formula [Ni(Abut)Ni(CN)<inf>4</inf> ]·8H<inf>2</inf> O (C1), [Cu(Abut)<inf>2</inf> Ni(CN)<inf>4</inf> ]·7H<inf>2</inf> O (C2), [Zn(Abut)Ni(CN)<inf>4</inf> ]·8H<inf>2</inf> O (C3) and [Cd(Abut)Ni(CN)<inf>4</inf> ]·7H<inf>2</inf> O (C4) were ob-tained by microwave synthesis method. The powder forms of the complexes were characterized by elemental, FT-IR spectroscopy, and thermal analysis. And also antibacterial, antibiofilm and anticancer activities were investigated. The splitting stretching bands of cyanido groups in the FT-IR spectra of C1-C4 indicated the assets of terminal and end cyanido groups. The antibacterial activities of C1-C4 were tested with nine Gram negative and six Gram positive bacteria. The most efficient antibacterial activity of complexes was observed at 1000 µg/ml-1 concentration. Anticancer activity was tested using HeLa cell line and MTT test. The studied cyanide complexes have been shown to decrease the viability of HeLa cells with IC<inf>50</inf> values 14.86, 6.5, 7.2 and 19.2 µg/ml for C1, C2, C3 and C4 complex, respectively. © 2022 Elsevier B.V., All rights reserved.