Taurine exhibits antioxidant, anti-inflammatory, and antiapoptotic effects against pyraclostrobin exposure in rats

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dc.contributor.authorSerim, Ibrahim
dc.contributor.authorDemirel, Hasan Huseyin
dc.contributor.authorZemheri Navruz, Fahriye
dc.contributor.authorInce, Sinan
dc.contributor.authorNavruz, Fahriye Zemheri
dc.date.accessioned2025-10-18T10:02:41Z
dc.date.created2024
dc.date.issued2024
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractPyraclostrobin, a strobilurin-derived fungicide, causes oxidative stress and DNA damage in the organism. Taurine plays an important role in metabolic processes such as osmoregulatory, cytoprotective, and antioxidant effects. The study aimed to investigate the protective effect of taurine in Sprague Dawley male rats exposed to pyraclostrobin. The rats were separated into 6 groups and were found 8 animals in each group. Rats were given 30 mg/kg pyraclostrobin and pyraclostrobin together with three different taurine concentrations (50, 100, and 200 mg/kg) via oral gavage for 28 days. While pyraclostrobin increased biochemical parameters, lipid peroxidation, and DNA damage, it decreased glutathione levels and enzyme activities of catalase and superoxide dismutase. Pyraclostrobin increased apoptotic, proinflammatory, and CYP2E1 mRNA expression levels, whereas antiapoptotic gene Bcl-2 mRNA expression levels decreased in liver tissue. Additionally, pyraclostrobin caused histopathological alterations in tissues. Taurine in a dose-dependent manner reversed the changes caused by pyraclostrobin. As a result, taurine exhibited a cytoprotective effect by showing antioxidant, anti-inflammatory, and antiapoptotic activities against oxidative damage caused by pyraclostrobin. Graphical Abstract
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Council of Turkey [20.SAG.BIL.29]
dc.description.sponsorshipThis study was financially supported by a grant from the Afyon Kocatepe University Scientific Research Council of Turkey (Project No: 20.SAG.BIL.29).
dc.identifier.doi10.1093/toxres/tfae120
dc.identifier.issn2045-452X
dc.identifier.issn2045-4538
dc.identifier.issue4
dc.identifier.orcidInce, Sinan/0000-0002-1915-9797
dc.identifier.orcidZEMHERI NAVRUZ, FAHRIYE/0000-0003-1744-1091
dc.identifier.pmid39100859
dc.identifier.urihttps://doi.org/10.1093/toxres/tfae120
dc.identifier.urihttps://hdl.handle.net/11772/20726
dc.identifier.volume13
dc.identifier.wosWOS:001288568500003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofToxicology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWoS_20251016
dc.subjectPyraclostrobin
dc.subjectTaurine
dc.subjectRat
dc.subjectAntioxidant
dc.subjectAnti-Inflammatory
dc.subjectAntiapoptotic
dc.titleTaurine exhibits antioxidant, anti-inflammatory, and antiapoptotic effects against pyraclostrobin exposure in rats
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationf79ec742-baba-48be-89fc-10f7ded30e19
relation.isAuthorOfPublication.latestForDiscoveryf79ec742-baba-48be-89fc-10f7ded30e19

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