SYNTHESIS AND FUNCTIONAL PROPERTIES OF DIPHENYLAMINE-CONTAINING SCHIFF BASES

Abstract

Schiff bases have been widely researched in vitro for their antimicrobial, antitumor, antiviral, antineoplastic, and antioxidant properties, owing to their strong chelating ability. Probiotics refer to “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host”. Thus, this study aims to investigate the antibacterial, anticancer, and antioxidant effects of Schiff Bases N-methylene-N-phenylbenzenaminium and N-(5-oxopentylidene)-N-phenylbenzenaminium, as well as their impact on some properties of probiotic bacteria, Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. Results indicate that these Schiff bases promote the growth of probiotic bacteria while inhibiting pathogenic bacteria. They demonstrate potent antibacterial and antioxidant activities, and cytotoxicity assays reveal that both compounds exert a high degree of inhibition on human colon and breast cancer cells. Additionally, there is significant modulation in auto-aggregation and surface hydrophobicity of Lactobacillus acidophilus and Lacticaseibacillus rhamnosus. In conclusion, the Schiff bases investigated in this study possess significant therapeutic potential.