A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

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dc.contributor.authorAkdemir, Fazile Nur Ekinci
dc.contributor.authorGülçin, İlhami
dc.contributor.authorKaragoz, Berna
dc.contributor.authorSoslu, Recep
dc.contributor.authorAlwasel, Saleh H.
dc.date.accessioned2025-10-18T10:05:13Z
dc.date.created2016
dc.date.issued2016
dc.departmentBartın Üniversitesi
dc.description.abstractThe antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA+I/R group. HES (100 mg/kg) has been given orally in the HES+1/R group. The left gastrocnemius muscle has been harvested and stored immediately at -80 degrees C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p<0.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p<0.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA+I/R and HES+I/R groups.
dc.description.sponsorshipCentral Research Laboratory of Agri Ibrahim Cecen University [SYO.14.002]; Research Chairs Program at King Saud University
dc.description.sponsorshipThe authors are grateful to Central Research Laboratory of Agri Ibrahim Cecen University for completely support of the work successfully approved by the Unit of Scientific Research Projects (project number: SYO.14.002). IG and SHA would like to extend their sincere appreciation to the Research Chairs Program at King Saud University for providing funding to this research.
dc.identifier.doi10.1080/14756366.2016.1220378
dc.identifier.endpage118
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.orcidSoslu, Recep/0000-0003-3751-063X
dc.identifier.orcidOZTURK KARAGOZ, BERNA/0000-0001-7187-1557;
dc.identifier.pmid27555116
dc.identifier.scopus2-s2.0-84983313737
dc.identifier.scopusqualityQ2
dc.identifier.startpage114
dc.identifier.urihttps://doi.org/10.1080/14756366.2016.1220378
dc.identifier.urihttps://hdl.handle.net/11772/21123
dc.identifier.volume31
dc.identifier.wosWOS:000391904900014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWoS_20251016
dc.subjectAntioxidant Activity
dc.subjectEllagic Acid
dc.subjectHesperidin
dc.subjectIschemia/Reperfusion Injury
dc.subjectSkeletal Muscle
dc.titleA comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury
dc.typeArticle
dspace.entity.typePublication

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