HPLC analysis, Phytochemical Content, and Biological Effects of Centaurea kilae Against Some Metabolic Enzymes: In Vitro and In Silico Studies

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dc.contributor.authorKısa, Dursun
dc.contributor.authorİmamoğlu, Rizvan
dc.contributor.authorGenc, Nusret
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKaya, Zafer
dc.contributor.authorTaskin-Tok, Tugba
dc.contributor.authorİmamoğlu, Rizvan
dc.contributor.authorKısa, Dursun
dc.contributor.authorTaslimi, Parham
dc.date.accessioned2025-10-18T09:58:45Z
dc.date.created2023
dc.date.issued2023
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.departmentFakülteler, Fen Fakültesi, Biyoteknoloji Bölümü
dc.description.abstractThe aim of this work was to quantify and identify the phenolic composition of Centaurea kilae Bosse and record the anti-alzheimer, anti-urease, anti-lipase, antidiabetic, anti-melanogenesis, and antibacterial properties. IC50 values for enzymes were obtained between 0.370-180.1 mu g/mL and this plant inhibited HMG_CoA R and urease enzymes more with IC50 values of 0.370 and 39.09 mu g/mL, respectively. Furthermore, molecular docking calculations were done subsequently, using targets, HMGCoA_R, glucosidase, amylase, and lipase to detect the structural necessity in activity for the phenolic compounds of Centaurea kilae plant. Chemical compounds of methanolic extracts of Centaurea kilae determined in this work. Finally, antibacterial and antifungal effects of this plant investigated.
dc.description.sponsorshipTUEBITAK (The Scientific and Technological Research Council of Turkey) [120Z005]
dc.description.sponsorshipThe present study was financially supported with a research grant coded 120Z005 by the TUEBITAK (The Scientific and Technological Research Council of Turkey). The authors thank Esin Aki Yalcin and the research group for technical assistance.
dc.identifier.doi10.1002/slct.202204196
dc.identifier.issn2365-6549
dc.identifier.issue6
dc.identifier.orcidIMAMOGLU, RIZVAN/0000-0002-6306-4760
dc.identifier.orcidKISA, Dursun/0000-0002-7681-2385
dc.identifier.orcidTASKIN-TOK, Tugba/0000-0002-0064-8400
dc.identifier.orcidTaslimi, Parham/0000-0002-3171-0633
dc.identifier.scopus2-s2.0-85147879899
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202204196
dc.identifier.urihttps://hdl.handle.net/11772/19820
dc.identifier.volume8
dc.identifier.wosWOS:000929178100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzWoS_20251016
dc.subjectCentaurea Kilae
dc.subjectPhenolic Compound
dc.subjectEnzyme Inhibition
dc.subjectIn Silico Study
dc.subjectAntimicrobial
dc.titleHPLC analysis, Phytochemical Content, and Biological Effects of Centaurea kilae Against Some Metabolic Enzymes: In Vitro and In Silico Studies
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication48078809-8159-4180-90c4-6675446d47bc
relation.isAuthorOfPublicationbfc44b0f-a825-4a67-805b-a4a08de214f9
relation.isAuthorOfPublicationdadfa319-65b8-4543-92b4-bea49e0139e9
relation.isAuthorOfPublication.latestForDiscovery48078809-8159-4180-90c4-6675446d47bc

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