Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity

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dc.contributor.authorSerdar, Burmaoglu
dc.contributor.authorAli O., Yilmaz
dc.contributor.authorTaslimi, Parham
dc.contributor.authorOztekin, Algul
dc.contributor.authorDeryanur, Kilic
dc.contributor.authorGülçin, İlhami
dc.contributor.authorTaslimi, Parham
dc.date.accessioned2019-05-07T13:38:15Z
dc.date.available2019-05-07T13:38:15Z
dc.date.created2018
dc.date.issued2018
dc.date.issuedyyyymmdd2018-02
dc.departmentFakülteler, Fen Fakültesi, Biyoteknoloji Bölümü
dc.description.abstractA series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.
dc.identifier.doi10.1002/ardp.201700314
dc.identifier.issue2
dc.identifier.startpagee1700314
dc.identifier.urihttps://hdl.handle.net/11772/1178
dc.identifier.volume351
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofArchiv der Pharmazie
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject-glycosidase
dc.subjectAcetylcholinesterase
dc.subjectButyrylcholinesterase
dc.subjectCarbonic anhydrase
dc.subjectPhloroglucinol derivatives
dc.titleSynthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationdadfa319-65b8-4543-92b4-bea49e0139e9
relation.isAuthorOfPublication.latestForDiscoverydadfa319-65b8-4543-92b4-bea49e0139e9

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