Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide

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dc.contributor.authorAcar, Umit
dc.contributor.authorInanan, Burak Evren
dc.contributor.authorZemheri Navruz, Fahriye
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorNavruz, Fahriye Zemheri
dc.date.accessioned2025-10-18T10:05:16Z
dc.date.created2021
dc.date.issued2021
dc.departmentFakülteler, Fen Fakültesi, Moleküler Biyoloji ve Genetik Bölümü
dc.description.abstractIn this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis nikticus) were investigated after a 14-day of exposure. After determination of LC50 value, effects of GBH on hematological and serum biochemical parameters in blood samples, DNA damage, lipid pemxidation and catalase activity in liver tissues, expression levels of antioxidant enzyme-related genes (SOD, CAT, GPx, and GST) and immune-related genes (TGF-beta, TGF-alpha and IL1-beta) were evaluated. The LC50 value has been found as 44.4 mg/L for GBH. GBH exposure at all concentrations caused alterations in blood parameters. GBH induced oxidative stress in liver and DNA damage in blood. Antioxidant enzyme-related genes were significantly up-regulated to suppress oxidative stress. On the other hand, the expression levels of immunerelated genes decreased in fish exposure to particularly >= 20 mg/L GBH.
dc.description.sponsorshipCanakkale Onsekiz Mart University Research Fund [2019/04-05]; [FBA-20192867]
dc.description.sponsorshipThis study was approved by the local ethical committee of Canakkale Onsekiz Mart University (ref. 2019/04-05) and supported by Canakkale Onsekiz Mart University Research Fund (Grant number: FBA-20192867).
dc.identifier.doi10.1016/j.cbpc.2021.109147
dc.identifier.issn1532-0456
dc.identifier.issn1878-1659
dc.identifier.pmid34332143
dc.identifier.scopus2-s2.0-85112578792
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.cbpc.2021.109147
dc.identifier.urihttps://hdl.handle.net/11772/21160
dc.identifier.volume249
dc.identifier.wosWOS:000693443600005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofComparative Biochemistry and Physiology C-Toxicology & Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzWoS_20251016
dc.subjectGlyphosate
dc.subjectNile Tilapia (Oreochromis Niloticus)
dc.subjectDna Damage
dc.subjectGene Expression
dc.subjectOxidative Stress
dc.titleAlterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationf79ec742-baba-48be-89fc-10f7ded30e19
relation.isAuthorOfPublication.latestForDiscoveryf79ec742-baba-48be-89fc-10f7ded30e19

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