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dc.contributor.authorÖztürk, Ayfer
dc.contributor.authorErdoğan, Hasan
dc.contributor.authorEkici, Fatih
dc.contributor.authorAydın, Duygu
dc.contributor.authorSöğüt, Erkan
dc.date.accessioned2019-05-17T12:00:00Z
dc.date.available2019-05-17T12:00:00Z
dc.date.issued2016
dc.identifier.citationÖztürk A, Erdoğan E, Ekici F, Aydın D, Söğüt E. Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels Streptozotocin Induced Diabetic Rats. West Indian Medical Journal 2016en_US
dc.identifier.issn2309-5830
dc.identifier.urihttp://hdl.handle.net/11772/1218
dc.description.abstractObjectives: Leptin and Endothelin (ET) as important endogenous factors interact with each other which may contribute to a better understanding their role in diabetic pathogenesis. We aimed to evaluate the relationship between Leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ETAR) antagonist, on Leptin levels in rats with diabetes induced by Streptozotocin (STZ). Methods: In this study, 24 male Wistar-albino rats were divided into three groups; Control, STZ, STZ+BQ-123 groups. Experimental diabetes was induced by delivering a single dose of 60 mg/kg intravenous STZ. The rats in the STZ+BQ-123 group received 4 mg/kg i.v.in total BQ-123 (2 mg/kg +2 mg/kg on the 39th and 40th days). The plasma specimens collected 6 hours after the last BQ-123 delivery were studied for biochemical parameters. Results: At the end of the experiment, the weights of rats in the STZ and STZ+BQ-123 groups were significantly lower compared with the values in the Control group. The levels of blood glucose were significantly higher in the STZ and STZ+BQ-123 groups than in the Control group. While rats with STZ-induced diabetes demonstrated no changes in Leptin, PC and K+ levels, they exhibited reduced NO, Na+ and Cl- concentrations. The levels of plasma TBARS was significantly higher in the STZ group than in the Control and STZ+BQ-123 groups. Conclusion: Although the levels of plasma Leptin was no statistically significant difference between the groups, BQ-123 groups lead to further decrease in reduced levels of Leptin than only diabetic group. Our findings have been considered that ETAR antagonists have positive impacts depending on the dosage in the diabetic rats.en_US
dc.language.isoengen_US
dc.publisherWest Indian Medical Journalen_US
dc.relation.isversionof10.7727/wimj.2016.106en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndothelin-1en_US
dc.subjectExperimental diabetesen_US
dc.subjectLeptinen_US
dc.subjectBQ-123en_US
dc.titleEffects of endothelin-a receptor antagonist bq-123 on plasma leptin levels streptozotocin induced diabetic ratsen_US
dc.typearticleen_US
dc.relation.journalWest Indian Medical Journalen_US
dc.contributor.departmentBartın Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US


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