Browsing Biyoteknoloji Bölümü by Author "Koçyiğit, Ümit M."
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Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties
Güzel, Emre; Koçyiğit, Ümit M.; Arslan, Barış S.; Ataş, Mehmet; Taslimi, Parham; Gökalp, Faik; Nebioğlu, Mehmet; Şişman, İlkay; Gulçin, İlhami (Wiley, 2019-02)The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ... -
Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats
Ilhami, Gulcin,; Taslimi, Parham; Koçyiğit, Ümit M.; Taşkıran, Ahmet Şevki; Yokus, Ahmet; Temel, Yusuf (Wiley, 2017-11)The aim of this study was to investigate the effects of oxytocin (OT), atosiban, which is an OT receptor antagonist, and OT-atosiban chemicals injected to rats on the activities of carbonic anhydrase (CA) and acetylcholinesterase ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Ilhami, Gulcin; Taslimi, Parham; Dastan, Taner; Koçyiğit, Ümit M.; Dastan, Sevgi Durna; Kılıçkaya, Pakize Cantürk; Çevik, Özge; Koparır, Metin; Orek, Cahit; Çetin, Ahmet (Wiley, 2017-11)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ... -
Synthesis and carbonic anhydrase inhibition of tetrabromo chalcone derivatives
Ilhami, Gulcin; Koçyiğit, Ümit M.; Budak, Yakup; Fikret, Eligüzel; Taslimi, Parham; Kılıç, Deryanur; Ceylan, Mustafa (Wiley, 2017-12)In the present study, human carbonic anhydrase (hCA) enzyme was purified and characterized from fresh blood human red cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity gel chromatography. Secondly, a series of new ... -
Synthesis, characterization, and SAR of arylated indenoquinoline‐based cholinesterase and carbonic anhydrase inhibitors
Ekiz, Makbule; Tutar, Ahmet; Ökten, Salih; Bütün, Burcu; Koçyiğit, Ümit M.; Taslimi, Parham; Topçu, Gülaçtı (Wiley, 2018-09)We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ...