Yazar "Gulcin, Ilhami" için Biyoteknoloji Bölümü listeleme
Toplam kayıt 12, listelenen: 1-12
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Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives
Oztaskin, Necla; Cetinkaya, Yasin; Taslimi, Parham; Goksu, Suleyman; Gulcin, Ilhami (Elsevier, 2015-06)In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions ... -
The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats
Turkan, Fikret; Huyut, Zubeyir; Taslimi, Parham; Gulcin, Ilhami (Taylor & Francis, 2019-01-01)In our study, it was aimed to investigate the effects of cefazolin, cefuroxime, and cefoperazon injected to rats on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme activities in the heart, brain, eye, ... -
The effects of some bromophenols on human carbonic anhydrase isoenzymes
Taslimi, Parham; Gulcin, Ilhami; Oztaskin, Necla; Cetinkaya, Yasin; Goksu, Suleyman; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016)Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to ... -
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
Bayrak, Cetin; Taslimi, Parham; Karaman, Halide Sedef; Gulcin, Ilhami; Menzek, Abdullah (Bioorganic Chemistry, 2019-04)Starting from vanillin, known four benzyl bromides with Br were synthesized. The first synthesis of natural product 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (2) and 3,4,6-tribromo-5-((methylsulfonyl) ... -
The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives
Taslimi, Parham; Gulcin, Ilhami; Ozgeris, Bunyamin; Goksu, Suleyman; Tumer, Ferhan; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016-01)Carbonic anhydrases (CAs, EC 4.2.1.1) had six genetically distinct families described to date in various organisms. There are 16 known CA isoforms in humans. Human CA isoenzymes I and II (hCA I and hCA II) are ubiquitous ... -
Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase
Ozgun, Dilan Ozmen; Yamali, Cem; Gul, Halise Inci; Taslimi, Parham; Gulcin, Ilhami; Yanik, Telat; Supuran, Claudiu T. (Informa, 2016)The effects of isatin Mannich bases incorporating (1-[piperidin-1-yl (P1)/morpholin-4-yl (P2)/N-methylpiperazin-1-yl (P3)]methyl)-1H-indole-2,3-dione) moieties against human (h) carbonic anhydrase (CA, EC 4.2.1.1) isoenzymes ... -
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
Kucukoglu, Kaan; Gul, Halise Inci; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Bioorganic Chemistry, 2019-02-04)Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, ... -
Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides
Gul, Halise Inci; Tugrak, Mehtap; Sakagami, Hiroshi; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Informa, 2016)A series of new 4-(3-(4-substitutedphenyl)-3a, 4-dihydro-3H-indeno[1,2-c] pyrazol-2-yl) benzenesulfonamides (7-12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and ... -
Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects
Gul, Halise Inci; Kucukoglu, Kaan; Yamali, Cem; Bilginer, Sinan; Yuca, Hafize; Ozturk, Iknur; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Informa, 2016)In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by H-1 NMR, (CNMR)-C-13, and HRMS. Ketones used were: Acetophenone (S1), ... -
Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Ozbey, Fadime; Taslimi, Parham; Gulcin, Ilhami; Maras, Ahmet; Goksu, Sueleyman; Supuran, Claudiu T. (Informa, 2016-12)A series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA) isoenzymes hCA I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory actions were investigated. The new ... -
The synthesis of some beta-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles
Turan, Burhanettin; Sendil, Kivilcim; Sengul, Emin; Gultekin, Mehmet Serdar; Taslimi, Parham; Gulcin, Ilhami; Supuran, Claudiu T. (Informa, 2016-12)beta-Lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a beta-lactam ring in their molecular structures. Synthesis of beta-lactam analogs, which are containing dichloride ... -
Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase
Sujayev, Afsun; Garibov, Emin; Taslimi, Parham; Gulcin, Ilhami; Gojayeva, Sevinj; Farzaliyev, Vagif; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016)2-(Methacryloyloxy)ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate, is a cyclic urea derivative synthesized from urea, 2-(methacryloyloxy) ethyl acetoacetate and substituted benzaldehyde, and tested ...