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In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4‐dihydro‐3H‐1,2, 4‐triazole‐3‐thiones—Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles
Timur, İrfan; Kocyigit, Ümit M.; Dastan, Taner; Sandal, Süleyman; Ceribası, Ali Osman; Taslimi, Parham; Gulcin, İlhami; Koparir, Metin; Karatepe, Mustafa; Çiftç, Mehmet (Wiley, 2019-01)The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities such as antimicrobial, analgesic, anti-inflammatory, antitumoural, cytotoxic, and antioxidant properties. In this study, a ... -
Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(-aminoalkyl)phosphinic acid derivatives against human breast cancer
Ilhami, Gulcin; Taslimi, Parham; Dastan, Taner; Koçyiğit, Ümit M.; Dastan, Sevgi Durna; Kılıçkaya, Pakize Cantürk; Çevik, Özge; Koparır, Metin; Orek, Cahit; Çetin, Ahmet (Wiley, 2017-11)The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel ...