Yazar "Gülçin, İlhami" için Biyoteknoloji Bölümü listeleme
Toplam kayıt 11, listelenen: 1-11
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Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes
Atmaca, Ufuk; Yıldırım, Alper; Taslimi, Parham; Çelik, Seda Tuncel; Gülçin, İlhami; Supuran, Claudiu T.; Çelik, Murat (Gulcin, I; Celik, M, 2018-08)In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f). carbonyl sulfonamides (3h and i). and carbonyl sulfamates (4h and 4i), which were tested against two ... -
Meta-Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, -glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties
Turker, Ferhat; Celepci, Duygu Barut; Celepci, Duygu Barut; Aktaş, Aydın; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Gülçin, İlhami (Wiley, 2018-07)meta-Cyanobenzyl-substituted N-heterocyclic carbene (NHC) precursors were synthesized by the reaction of a series of N-(alkyl)benzimidazolium with 3-bromomethyl-benzonitrile. These benzimidazolium salts were characterized ... -
Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
Kuzu, Burak; Tan, Meltem; Taslimi, Parham; Gülçin, İlhami; Taşpınar, Mehmet; Menges, Nurettin (Bioorganic Chemistry, 2019-01-24)Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ... -
Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties
Aktaş, Aydın; Celepci, Duygu Barut; Kaya, Ruya; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Gülçin, İlhami (POLYHEDRON, 2019-02-01)This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation ... -
Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties
Daryadel, Shahla; Atmaca, Ufuk; Taslimi, Parham; Gülçin, İlhami; Çelik, Murat (Wiley, 2018-11)Sulfamates have a large spectrum of biological activities including enzyme inhibition. Eight sulfamates derived from menthol (2a-h) were synthesized. Also, in the other section of this study, novel sulfamate derivatives ... -
Phytochemical content, antioxidant activity, and enzyme inhibition effect of Salvia eriophora Boiss. & Kotschy against acetylcholinesterase, α‐amylase, butyrylcholinesterase, and α‐glycosidase enzymes
Bursal, Ercan; Aras, Abdulmelik; Kılıç, Ömer; Taslimi, Parham; Gören, Ahmet C.; Gülçin, İlhami (Journal Of Food Biochemistry, 2019-03)Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC-MS/MS ... -
Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors
Yiğit, Beyhan; Yiğit, Murat; Taslimi, Parham; Gök, Yetkin; Gülçin, İlhami (Wiley, 2018-09)Three series of symmetrical Schiff bases were synthesized from 1,2-diaminoethane, 1,3-diaminopropane and 1,4-diaminobutane and substituted benzaldehydes, and reduced by sodium borohydride to the corresponding benzylic ... -
Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones
Kocyigit, Umit M.; Budak, Yakup; Gürdere, Meliha Burcu; Dürü, Neşe; Taslimi, Parham; Gülçin, İlhami; Ceylan, Mustafa (MONATSHEFTE FUR CHEMIE, 2019-04)A series of novel 1,3,5-trisubstituted pyrazoline derivatives, (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones, were ... -
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
Turkan, Fiket; Çetin, Adnan; Taslimi, Parham; Karaman, Muhammet; Gülçin, İlhami (Elsevier, 2019-05)A series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1–8 and 9a, b) were emerged as ... -
Synthesis, characterization and crystal structure of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl Substituted Benzimidazole Bromide Salts: Their inhibitory properties against carbonic anhydrase and acetylcholinesterase
Behçet, Ayten; Çağlılar, Tuba; Celepci, DuyguBarut; Aktaş, Aydın; Taslimi, Parham; Gök, Yetkin; Aygün, Muhittin; Kaya, Ruya; Gülçin, İlhami (Elsevier, 2018-10-15)This paper reports the synthesis of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts. The benzimidazolium salts were synthesized by N-substituted benzimidazolium and aryl halides. The ... -
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
Ökten, Salih; Ekiz, Makbule; Koçyiğit, Ümit Muhammet; Tutar, Ahmet; Çelik, İsmail; Akkurt, Mehmet; Gökalp, Faik; Taslimi, Parham; Gülçin, İlhami (Elsevier, 2019-01-05)The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...