Biyoteknoloji Bölümü: Recent submissions
Now showing items 81-100 of 116
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Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
(Wiley, 2018-08)In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ... -
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
(Bioorganic Chemistry, 2019-04)Starting from vanillin, known four benzyl bromides with Br were synthesized. The first synthesis of natural product 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (2) and 3,4,6-tribromo-5-((methylsulfonyl) ... -
Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes
(Gulcin, I; Celik, M, 2018-08)In this study, we aimed to determine the inhibition effects of novel synthesized sulfamates (2a-g), sulfonamides (3b-f). carbonyl sulfonamides (3h and i). and carbonyl sulfamates (4h and 4i), which were tested against two ... -
Synthesis and investigation of anticancer, antibacterial activities and carbonic anhydrase, acetylcholinesterase inhibition profiles of novel (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones
(MONATSHEFTE FUR CHEMIE, 2019-04)A series of novel 1,3,5-trisubstituted pyrazoline derivatives, (3aR,4S,7R,7aS)-2-[4-[1-acetyl-5-(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl]-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-diones, were ... -
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
(Bioorganic Chemistry, 2019-02-04)Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, ... -
Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases
(Bioorganic Chemistry, 2019-01-24)Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the ... -
Novel morpholine liganded Pd-based N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure, antidiabetic and anticholinergic properties
(POLYHEDRON, 2019-02-01)This study involves the synthesis of novel N-heterocyclic carbene (NHC)PdX2(morpholine) complexes (1a-i). These Pd-based complexes are synthesized from pyridine enhanced precatalyst preparation stabilization and initiation ... -
Synthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymes
(Bioorganic Chemistry, 2019-03)A new coordination polymer Zn(II) with thiosemicarbazone glyoxalic acid H(2)GAT was obtained in this study. According to the X-ray diffraction data, the coordination of the Zn(II) ion is carried out by one sulfur atom, in ... -
Five complexes containing N,N-bis(2hydroxyethyl)-ethylenediamine with tetracyanidopalladate(II): synthesis, crystal structures, thermal, magnetic, and catalytic properties
(Taylor & Francis, 2013-08-14)Five cyanide complexes, [Ni(N-bishydeten)Pd(CN)4]( 1), [Cu(N-bishydeten)Pd(μ-CN)2(CN)2]n (2), [Cu(N-bishydeten)2][Pd(CN)4]( 3), [Zn(N-bishydeten)Pd(CN)4]( 4), and [Cd(N-bishydeten)2][Pd (CN)4]( 5)(N-bishydeten = ... -
In vitro biological properties and predicted DNA–BSA interaction of three new dicyanidoargentate(I)-based complexes: synthesis and characterization
(The Royal Society of Chemistry, 2018-03-01)The reaction of certain metal salts with N,N0-bis(2-hydroxyethyl)ethylenediamine (bishydeten) and [Ag(CN)2] resulted in [Ni(bishydeten)2][Ag(CN)2]2 H2O (C1), [Cu(bishydeten)2Ag2(CN)4] (C2) and [Cd(bishydeten)0.5]2[Ag(CN)2]4 ... -
New bimetallic dicyanidoargentate(I)-based coordination compounds: Synthesis, characterization, biological activities and DNA-BSA binding affinities
(Elsevier, 2017-01-01)Four compounds -two (2 and 3) completely new- of composition [Ni(edbea)Ag3(CN)5] (1), [Cu(edbea)Ag2(CN)4]·H2O (2), [Cd(edbea)Ag3(CN)5]·H2O (3) and [Cd(edbea)2] [Ag(CN)2]2·H2O (4) {edbea; 2,2′-(ethylenedioxy)bis (ethylamine)}, ... -
Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease
(Wiley, 2019-03)Multiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy ... -
Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Elsevier, 2019-05)A series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1–8 and 9a, b) were emerged as ... -
Tetrasiyanometalat içeren komplekslerin sentezi, çeşitli tekniklerle yapısal tanımlamaları ve termik özelliklerinin incelenmesi
(ÇANAKKALE ONSEKİZ MART ÜNİVERSİTESİ-FEN EDEBİYAT FAKÜLTESİ-KİMYA BÖLÜMÜ, 2011-05) -
Yeni siyano köprülü heteronükleer koordinasyon kompleksleri ve bunların farmasötik madde olarak kullanımı
(Türk Patent Enstitüsü, 2013-08-22)Buluş, yeni dinükleer siyano köprülü koordinasyon polimerleriyle ilgilidir. Daha özel bir ifadeyle buluş metal iyonlarının, yani bakır, çinko veya kadmiyumun 2,2'-(etilendioksi)bis(etilamin) ligandı ve disiyanoargentat ... -
Sentetik peptidli yara bandı
(KTÜ Proje Pazarı, 2018)Günümüz biyoteknolojisinde biyomedikal alanda birçok yenilik yapılmaktadır.yapılan yenilikler karşılaşılan sağlık sorunlarına en kısa sürede çözüm aramaya yöneliktir.bilim insanları güçlü ve geniş antimikrobiyal aktiviteleri ... -
TOREX: Yerli ve milli temizlik ve kişisel bakım ürünleri
(TOKAT AR-GE PROJE PAZARI, 2018-10-11)TOREX;TOkat ve REşadiye isimlerinden mülhem,isim tescili alınmış olan temizlik ve kişisel bakım ürünleri markasıdır.vizyonumuz, çevreye ve insan sağlığına önem veren ürünler üreterek dünya çapında tercih edilen markalardan ... -
Determination of anticancer activities and mechanism of action of a new coordination compound containing Agi(CN)2
(IUPAC (International Union of Pure and Applied Chemistry), 2013-08-12)The main goals of the present study were to determine the anticancer activity of a new cyano-bridged {Ag I (CN) 2} coordination compound, coded as AN5 (C16H34Ag2N8NiO5) on some cancer cell lines in vitro and enlighten it’s ... -
Önemli antikanserojen, antimikrobiyal ve antifungal aktiviteye sahip yeni disiyanidogümüş(I) esaslı kompleksler
(Kimyevi maddeler ve mamulleri sektöründe 3.AR-GE Proje pazarı, 2013) -
Fabrikaların petrol,petrol türevleri ve yağ atıklarından Alcanivorax Borkumensis bakterisi kullanılarak arındırılması
(BARTIN II. AR-GE PROJE PAZARI, 2018-05-10)
