Browsing Fen Fakültesi by Author "Ilhami, Gulcin"
Now showing items 21-30 of 30
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Synthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivatives
Taslimi, Parham; Cuneyt, Caglayan; Vagif, Farzaliyev; Oruj, Nabiyev; Afsun, Sujayev; Fikret, Turkan; Ruya, Kaya; Ilhami, Gulcin (Wiley, 2018-04)During this investigation, N,N'-bis-azidomethylamines, N,N'-bis-cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, ... -
Synthesis and investigation of antibacterial activities and carbonic anhydrase and acetyl cholinesterase inhibition profiles of novel 4,5-dihydropyrazol and pyrazolyl-thiazole derivatives containing methanoisoindol-1,3-dion unit
Yakup, Budak; Umit M., Kocyigit; Meliha Burcu, Gurdere; Kezban, Ozcan; Parham, Taslimi; Ilhami, Gulcin; Mustafa, Ceylan (Taylor & Francis, 2017)Novel 4,5-dihydropyrazole derivatives (3a-i), 3-(4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)phenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carbothio amide, were obtained by the addition ... -
Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities
Parham, Taslimi; Afsun, Sujayev; Fikret, Turkan; Emin, Garibov; Zubeyir, Huyut; Vagif, Farzaliyev; Sevgi, Mamedova; Ilhami, Gulcin (Wiley, 2018-02)The conversion reactions of pyrimidine-thiones with nucleophilic reagent were studied during this scientific research. For this purpose, new compounds were synthesized by the interaction between 1,2-epoxy propane, 1,2-epoxy ... -
Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities
Emin, Garibov; Taslimi, Parham; Afsun, Sujayev; Zeynebe, Bingol; Songul, Cetinkaya; Ilhami, Gulcin; Sukru, Beydemir; Vagif, Farzaliyev; Saleh H., Alwasel; Claudiu T., Supuran (Informa, 2016-12)A series of tetrahydropyrimidinethiones were synthesized from thiourea, -diketones and aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde, salicylaldehyde and benzaldehyde. These cyclic thioureas ... -
Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles
Umit Muhammet, Kocyigit; Yakup, Budak; Meliha Burcu, Gurdere; Fatih, Erturk; Belkiz, Yencilek; Taslimi, Parham; Ilhami, Gulcin; Mustafa, Ceylan (Taylor & Francis, 2018)The new 1-(4-(3-(aryl)acryloyl)phenyl)-1H-pyrrole-2,5-diones (5a-g) were prepared from 4-aminchalcones (3a-g) and screened for biological activities. All compounds (3a-g and 5a-g), except 3d and 3e displayed good cytotoxic ... -
Synthesis of mannich bases by two different methods and evaluation of their acetylcholine esterase and carbonic anhydrase inhibitory activities
Halise I., Gul; Alkan, Demirtas; Gokbay, Ucar; Taslimi, Parham; Ilhami, Gulcin (Letters in Drug Design & Discovery, 2017)Background: Mannich bases are an important compounds in medicinal chemistry. They have wide range of biological activities including carbonic anhydrase (CA) inhibitory and acetylcholine esterase inhibitory (AChE) activities. ... -
Synthesis of new cyclic thioureas and evaluation of their metal-chelating activity, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibition profiles
Taslimi, Parham; Afsun, Sujayev; Emin, Garibov; Nazar, Nazarov; Zubeyir, Huyut; Saleh H., Alwasel; Ilhami, Gulcin (Wiley, 2017-07)In the presence of trifluoracetic acid (TFAA), an efficient method for the synthesis of tetra(hexa)hydropyrimidinethione-carboxylates has been used on the basis of three-component condensation of thiourea with its different ... -
Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles
Nilufer, Bulut; Umit M., Kocyigit; Ibrahim H., Gecibesler; Taner, Dastan; Huseyin, Karci; Taslimi, Parham; Sevgi Durna, Dastan; Ilhami, Gulcin; Ahmet, Cetin (Wiley, 2018-01)Some novel derivatives of thiosemicarbazide and 1,2,4-triazole-3-thiol were synthesized and evaluated for their biological activities. The title compounds were prepared starting from readily available pyridine-2,5-dicarboxylic ... -
Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines
Halise Inci, Gul; Parham, Taslimi; Ilhami, Gulcin; Claudiu T., Supuran (Informa, 2017)4-(3-(4-Substituted-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl) benzenesulfonamides (9-16) were successfully synthesized and their chemical structures were confirmed by H-1 NMR, C-13 NMR, and HRMS spectra. Carbonic ... -
Synthesis, molecular modeling, and biological evaluation of 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and II enzymes
Cem, Yamali; Halise Inci, Gul; Abdulilah, Ece; Taslimi, Parham; Ilhami, Gulcin (Wiley, 2018-04)In this study, 4-[5-aryl-3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl] benzenesulfonamides were synthesized, and inhibition effects on AChE, hCA I, and hCA II were evaluated. K-i values of the compounds toward hCA I were ...