Browsing Fen Fakültesi by Author "Tutar, Ahmet"

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Synthesis, characterization, and SAR of arylated indenoquinoline‐based cholinesterase and carbonic anhydrase inhibitors

Ekiz, Makbule; Tutar, Ahmet; Ökten, Salih; Bütün, Burcu; Koçyiğit, Ümit M.; Taslimi, Parham; Topçu, Gülaçtı (Wiley, 2018-09)

We report the synthesis of bromoindenoquinolines (15a-f) by Friedlander reactions in low yields (13-50%) and the conversion of the corresponding phenyl-substituted indenoquinoline derivatives 16-21 in high yields (80-96%) ...
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors

Ökten, Salih; Ekiz, Makbule; Koçyiğit, Ümit Muhammet; Tutar, Ahmet; Çelik, İsmail; Akkurt, Mehmet; Gökalp, Faik; Taslimi, Parham; Gülçin, İlhami (Elsevier, 2019-01-05)

The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...