Ara
Toplam kayıt 352, listelenen: 101-110
The first synthesis, carbonic anhydrase inhibition and anticholinergic activities of some bromophenol derivatives with S including natural products
(Bioorganic Chemistry, 2019-04)
Starting from vanillin, known four benzyl bromides with Br were synthesized. The first synthesis of natural product 3,4-dibromo-5-((methylsulfonyl)methyl)benzene-1,2-diol (2) and 3,4,6-tribromo-5-((methylsulfonyl) ...
Lise öğrencilerinin güvenli bilgisayar ve internet kullanım farkındalıklarının incelenmesi: bartın ili örneği
(2017)
Information and Communication Technologies (ICT) have been rapidly prevailed among the children and youths. Personal technologies facilitating the students to gain some learning experiences both in and out of the schools ...
Çevrimiçi ve geleneksel yüz yüze hizmet içi eğitim uygulamalarının karşılaştırılması: deneysel bir çalışma
(2017)
Bu araştırmanın amacı öğretmenlere yönelik yüz yüze ve çevrimiçi uzaktan eğitim yöntemiyle verilecek bir hizmet içi eğitim sürecini gerçekleştirmek ve bu eğitimin etkisini bilgisayar okuryazarlığı boyutunda değerlendirmektir. ...
Comparison of online and traditional face-to-face in-service training practices: an experimental study
(2017)
The purpose of this study is to carry out the process of conducting an in-service education process via face-to-face and online distance education methods and to evaluate the impact of this ...
Multiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer’s disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α‐glycosidase, α‐amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against α‐glycosidase and 3.3 nM against α‐amylase, respectively. In contrast, Ki values were found of 50.96 ± 2.18 μM against AChE and 53.17 ± 4.47 μM against BChE. α‐Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.
(Bentham Science, 2019)
Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and ...
Synthesis, characterization, crystal structures, theoretical calculations and biological evaluations of novel substituted tacrine derivatives as cholinesterase and carbonic anhydrase enzymes inhibitors
(Elsevier, 2019-01-05)
The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9-11) were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives were characterized by NMR spectroscopy, ...
Synthesis, crystal structure, and biological evaluation of optically active 2‐amino‐4‐aryl‐7,7‐dimethyl‐5‐oxo‐5,6,7,8‐tetrahydro‐4H‐chromen‐3‐carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentials
(Wiley, 2019-02)
In the presence of chiral organic catalysts, the optically active 4H-chromine was synthesized from the multicomponent condensation of 5,5-dimethylcyclohexane-1,3-dione with malononitrile and methylene-active compound, and ...
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
(Wiley, 2018-08)
In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ...
Disiyanogümüş(ı) içeren siyano köprülü koordinasyon polimerinin antimikrobiyal özelliğinin incelenmesi
(GAZİOSMANPAŞA ÜNİVERSİTESİ/FEN EDEBİYAT FAKÜLTESİ/KİMYA BÖLÜMÜ, 2013-06)
Revize edilmiş işlemsel uzaklık ölçeğinin uyarlama çalışması
(2016)
Bu araştırma kapsamında; revize edilmiş işlemsel uzaklık ölçeğinin Türk kültürüne uyarlanması ve ölçeğin geçerlilik ve güvenilirlik analizlerinin gerçekleştirilmesi amaçlanmıştır. Araştırma 227 üniversite öğrencisinden ...