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Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia

Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Oztaskin, Necla; Maraş, Ahmet; Gulçin, İlhami; Beydemir, Sukru; Goksu, Suleyman (Elsevier, 2018-11)

Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ...

Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes

Demir, Yeliz; Taslimi, Parham; Ozaslan, Muhammet Serhat; Oztaskin, Necla; Çetinkaya, Yasin; Gulçin, İlhami; Beydemir, Şükrü; Goksu, Suleyman (Wiley, 2018-12)

Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ...