Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions

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dc.contributor.authorOzbey, Fadime
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGülçin, İlhami
dc.contributor.authorMaras, Ahmet
dc.contributor.authorGoksu, Sueleyman
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorTaslimi, Parham
dc.date.accessioned2019-06-13T06:45:31Z
dc.date.available2019-06-13T06:45:31Z
dc.date.created2016
dc.date.issued2016
dc.date.issuedyyyymmdd2016-12
dc.departmentFakülteler, Fen Fakültesi, Biyoteknoloji Bölümü
dc.description.abstractA series of diaryl ethers were synthesized and their human (h) carbonic anhydrase (CA) isoenzymes hCA I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory actions were investigated. The new compounds were synthesized from the corresponding phenols and bromobenzenes via the Ullmann reaction, by using dipicolinic acid as a copper (I) complexing ligand. hCA I and II were inhibited with K(i)s in the low nanomolar range of 102.01-127.13nM against hCA I, and of 73.71-113.40nM against hCA II, whereas the inhibition constants against AChE were of 15.35-18.34nM and against BChE in the range of 9.07-22.90nM. The CA inhibition mechanism with these ethers is unknown, but may be similar to that of aryl methyl ethers investigated earlier by computational approaches.
dc.identifier.doi10.1080/14756366.2016.1189422
dc.identifier.endpage85
dc.identifier.startpage79
dc.identifier.urihttps://hdl.handle.net/11772/1388
dc.identifier.volume31
dc.language.isoen
dc.publisherInforma
dc.relation.ispartofJournal of Enzyme Inhibition and Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAcetylcholinesterase;
dc.subjectButyrylcholinesterase
dc.subjectCarbonic anhydrase
dc.subjectDiaryl ethers
dc.subjectEnzyme inhibition
dc.titleSynthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationdadfa319-65b8-4543-92b4-bea49e0139e9
relation.isAuthorOfPublication.latestForDiscoverydadfa319-65b8-4543-92b4-bea49e0139e9

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