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dc.contributor.authorTurkan, Fiket
dc.contributor.authorÇetin, Adnan
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKaraman, Muhammet
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2019-04-25T09:15:36Z
dc.date.available2019-04-25T09:15:36Z
dc.date.issued2019-05
dc.identifier.issn0045-2068
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0045206818314202?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/11772/1080
dc.description.abstractA series of substituted pyrazole compounds (1–8 and 9a, b) were synthesized and their structure was characterized by IR, NMR, and Mass analysis. These obtained novel pyrazole derivatives (1–8 and 9a, b) were emerged as effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II) and acetylcholinesterase (AChE) enzymes with Ki values in the range of 1.03 ± 0.23–22.65 ± 5.36 µM for hCA I, 1.82 ± 0.30–27.94 ± 4.74 µM for hCA II, and 48.94 ± 9.63–116.05 ± 14.95 µM for AChE, respectively. Docking studies were performed for the most active compounds, 2 and 5, and binding mode between the compounds and the receptors were determined.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bioorg.2019.02.013en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubstituted pyrazoleen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitorsen_US
dc.typearticleen_US
dc.relation.journalBioorganic Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume86en_US
dc.identifier.startpage420en_US
dc.identifier.endpage427en_US


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