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Now showing items 1-20 of 91

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      2-Hydroxyethyl substituted NHC precursors: Synthesis, characterization, crystal structure and carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties 

      Fatos, Erdemir; Duygu Barut, Celepci; Aydin, Aktas; Parham, Taslimi; Yetkin, Gok; Hasan, Karabiyik; Ilhami, Gulcin (Elsevier, 2018-03-05)
      This study contains novel a serie synthesis of N-heterocyclic carbene (NHC) precursors that 2-hydroxyethyl substituted. The NHC precursors have been prepared from 1-(2-hydroxyethyl)benzimidazole and alkyl halides. The novel ...
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      Aminopyrazole‐substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties 

      Güzel, Emre; Koçyiğit, Ümit M.; Arslan, Barış S.; Ataş, Mehmet; Taslimi, Parham; Gökalp, Faik; Nebioğlu, Mehmet; Şişman, İlkay; Gulçin, İlhami (Wiley, 2019-02)
      The synthesis, characterization, aggregation behavior, theoretical studies, and investigation of antimicrobial, antidiabetic, and anticholinergic properties of 4-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)eth ...
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      Anticancer activities and mechanism of action of 2 novel metal complexes, C16H34N8O5Ag2Cd and C11H16N7O2Ag3Ni 

      Korkmaz, Nesrin; Karadağ, Ahmet (TÜBİTAK, 2014-11-24)
      The discovery of anticancer activity in cisplatin triggered the development of novel drugs containing metals such as platinum or ruthenium. Extremely diverse structural chemistry and the interaction of metal complexes with ...
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      Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes 

      Gulçin, İlhami; Taslimi, Parham; Aygün, Ayşenur; Sadeghian, Nastaran; Bastem, Enes; Kufrevioglu, Omer Irfan; Turkan, Fikret; Şen, Fatih (Elsevier, 2018-11)
      The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity column chromatography. Also, alpha-amylase from porcine pancreas and alpha-glycosidase from Saccharomyces cerevisiae were used ...
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      Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes 

      Demir, Yeliz; Taslimi, Parham; Ozaslan, Muhammet Serhat; Oztaskin, Necla; Çetinkaya, Yasin; Gulçin, İlhami; Beydemir, Şükrü; Goksu, Suleyman (Wiley, 2018-12)
      Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ...
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      Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes 

      Parham, Taslimi; Ilhami, Gulcin (Wiley, 2017-10)
      -Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase ...
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      Antioxidant activity of the aqueous extract of iris taochia and identification of its chemical constituents 

      Askin, H.; Yilmaz, B.; Gulcin, I.; Taslimi, Parham; Bakirci, S.; Yildiz, M.; Kandemir, N. (Indian Journal of Pharmaceutical Sciences, 2018-09)
      In this study, phytochemical components and antioxidant capacity of extracts obtained from Iris taochia plant, which is endemic to Caucasus, were investigated. Fifteen new compounds were detected and identified using a ...
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      Antioxidant activity, acetylcholinesterase, and carbonic anhydrase inhibitory properties of novel ureas derived from phenethylamines 

      Kadir, Aksu; Bunyamin, Ozgeris; Taslimi, Parham; Ali, Naderi; Ilhami, Gulcin; Suleyman, Goksu (Wiley, 2016-12)
      A series of ureas derived from phenethylamines were synthesized and evaluated for human carbonic anhydrase (hCA) I and II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzyme inhibitory activities and ...
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      Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives 

      Oztaskin, Necla; Cetinkaya, Yasin; Taslimi, Parham; Goksu, Suleyman; Gulcin, Ilhami (Elsevier, 2015-06)
      In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions ...
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      Antioxidant and anticholinergic properties of olivetol 

      Taslimi, Parham (Wiley, 2018-06)
      Olivetol is a pioneer in diverse syntheses of tetrahydrocannabinol. It is produced by a type of insects, which is used as a pheromone, antiseptic, or repellent agent. In this study, we evaluated the antioxidant properties ...
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      Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep 

      Kocyigit, Umit M.; Taslimi, Parham; Gulçin, İlhami (Wiley, 2018-08)
      In this work, the carbonic anhydrase (CA) enzyme was purified from Kangal Akkaraman sheep in Sivas, Turkey with specific activity value of 6681.57 EU/mg and yield of 14.90% with using affinity column chromatography. For ...
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      Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic approach in diabetes and functional hyperglycemia 

      Taslimi, Parham; Aslan, Hatice Esra; Demir, Yeliz; Oztaskin, Necla; Maraş, Ahmet; Gulçin, İlhami; Beydemir, Sukru; Goksu, Suleyman (Elsevier, 2018-11)
      Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase superfamily and plays a key role in the polyol ...
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      Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base 

      Parham, Taslimi; Sabiya, Osmanova; Ilhami, Gulcin; Sabira, Sardarova; Vagif, Farzaliyev; Afsun, Sujayev; Ruya, Kaya; Fatma, Koc; Sukru, Beydemir; Saleh H., Alwasel; Omer Irfan, Kufrevioglu (Wiley, 2017-09)
      Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ...
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      The effects of hesperidin on sodium arsenite-induced different organ toxicity in rats on metabolic enzymes as antidiabetic and anticholinergics potentials: A biochemical approach 

      Caglayan, Cuneyt; Demir, Yeliz; Kucukler, Sefa; Taslimi, Parham; Kandemir, Fatih Mehmet; Gulçin, İlhami (Wiley, 2019-02)
      In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 ...
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      The effects of some antibiotics from cephalosporin groups on the acetylcholinesterase and butyrylcholinesterase enzymes activities in different tissues of rats 

      Turkan, Fikret; Huyut, Zubeyir; Taslimi, Parham; Gulcin, Ilhami (Taylor & Francis, 2019-01-01)
      In our study, it was aimed to investigate the effects of cefazolin, cefuroxime, and cefoperazon injected to rats on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzyme activities in the heart, brain, eye, ...
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      The effects of some bromophenols on human carbonic anhydrase isoenzymes 

      Taslimi, Parham; Gulcin, Ilhami; Oztaskin, Necla; Cetinkaya, Yasin; Goksu, Suleyman; Alwasel, Saleh H.; Supuran, Claudiu T. (Informa, 2016)
      Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to ...
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      The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats 

      Umit Muhammet, Kocyigit,; Taslimi, Parham; Fatih, Gurses; Sinan, Soylu; Sevgi Durna, Dastan; Ilhami, Gulcin (Wiley, 2018-03)
      The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For ...
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      Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes 

      Umit M., Kocyigit; Taslimi, Parham; Hayreddin, Gezegen; Ilhami, Gulcin; Mustafa, Ceylan (Wiley, 2017-09)
      Carbonic anhydrase (CA; EC 4.2.1.1) is used for remedial purposes for several years, as there is significant focus on expanding more new activators (CAAs) and high affinity inhibitors. Alzheimers disease and other similar ...
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      The first synthesis and antioxidant and anticholinergic activities of 1-(4,5-dihydroxybenzyl)pyrrolidin-2-one derivative bromophenols including natural products 

      Mohsen, Rezai; Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Turkish Journal of Chemistry, 2018)
      We report herein the first synthesis of biologically active natural bromophenols, namely 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)pyrrolidin-2-one (2), 2RS-1- (2 ,3-dibromo-4 ,5-dihydroxybenz yl)-5-oxopyrrolidine-2-carboxylic ...
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      The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes 

      Cetin, Bayrak; Taslimi, Parham; Ilhami, Gulcin; Abdullah, Menzek (Elsevier, 2017-06)
      The first synthesis of (E)-4-(3-bromo-4,5-dihydroxyphenyl) but-3-en-2-one (1), (E)-4-(2-bromo-4,5-dihy droxyphenyl) but-3-en-2-one (2), and (E)-4-(2,3-dibromo-4,5-dihydroxyphenyl) but-3-en-2-one (3) was realized as natural ...

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