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dc.contributor.authorTürkan, Fikret
dc.contributor.authorTaslimi, Parham
dc.contributor.authorSaltan, Fatma Zerrin
dc.date.accessioned2019-04-25T09:16:34Z
dc.date.available2019-04-25T09:16:34Z
dc.date.issued2019-03
dc.identifier.issn1099-0461
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jbt.22340
dc.identifier.urihttp://hdl.handle.net/11772/1081
dc.description.abstractMultiple studies have been recorded on the synthesis and design of multi‐aim anti‐Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer's disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), α‐glycosidase, α‐amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against α‐glycosidase and 3.3 nM against α‐amylase, respectively. In contrast, Ki values were found of 50.96 ± 2.18 µM against AChE and 53.17 ± 4.47 µM against BChE. α‐Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/jbt.22340en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticholinergicsen_US
dc.subjectAntidiabeticen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectMetabolic enzymesen_US
dc.subjectTannic aciden_US
dc.titleTannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's diseaseen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US


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