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dc.contributor.authorHuseynova, Mansura
dc.contributor.authorMedjidov, Ajdar
dc.contributor.authorTaslimi, Parham
dc.contributor.authorAliyeva, Mahizar
dc.date.accessioned2019-04-29T07:15:13Z
dc.date.available2019-04-29T07:15:13Z
dc.date.issued2019-03
dc.identifier.urihttp://hdl.handle.net/11772/1115
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0045206818309441
dc.description.abstractA new coordination polymer Zn(II) with thiosemicarbazone glyoxalic acid H(2)GAT was obtained in this study. According to the X-ray diffraction data, the coordination of the Zn(II) ion is carried out by one sulfur atom, in the thiol form, one nitrogen atom of the azomethine group and two oxygen atoms of the carboxylate groups, one of which belongs to neighbouring complex molecule. The oxygen atom of the water molecule completes Zn(II) ion environment to a distorted square-pyramidal structure. The binding of the monomer complex into polimer occurs through the bridge oxygen atom of carboxylate group. This complex is effective inhibitor of the alpha-glycosidase, butyrylcholinesterase (BChE), cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase enzymes (AChE) enzymes with Ki values of 1.45 +/- 0.23 mu M for hCA I, 2.04 +/- 0.11 mu M for hCA II, 3.47 +/- 0.88 mu M for alpha-glycosidase, 0.47 +/- 0.10 mu M for BChE, and 0.58 +/- 0.13 mu M for AChE, respectively.en_US
dc.language.isoengen_US
dc.publisherBioorganic Chemistryen_US
dc.relation.isversionof10.1016/j.bioorg.2018.10.012en_US
dc.relation.isversionof10.1016/j.bioorg.2018.10.012
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiosemicarbazonesen_US
dc.subjectZn-complexen_US
dc.subjectCrystal structureen_US
dc.subjectAntidiabeticen_US
dc.subjectAnticholinergicsen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis, characterization, crystal structure of the coordination polymer Zn(II) with thiosemicarbazone of glyoxalic acid and their inhibitory properties against some metabolic enzymesen_US
dc.typearticleen_US
dc.relation.journalBioorganic Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume83en_US
dc.identifier.startpage55en_US
dc.identifier.endpage62en_US


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