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dc.contributor.authorYigit, Beyhan
dc.contributor.authorYigit, Murat
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorGok, Yetkin
dc.contributor.authorAktas, Aydin
dc.contributor.authorAygun, Muhittin
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulcin, Ilhami Ilhami
dc.date.accessioned2019-04-29T07:57:00Z
dc.date.available2019-04-29T07:57:00Z
dc.date.issued2018-07-23
dc.identifier.urihttp://hdl.handle.net/11772/1123
dc.description.abstractThe new imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts were synthesized in good yield by the reaction of the corresponding N,N'-dialkylalkanediamine with triethyl orthoformate in the presence of ammonium chloride. All of the compounds were obtained, and spectroscopically characterized. The crystal structure for the 1,3-bis(4-benzyloxy-3-methoxybenzyl)-3,4,5,6-tetrahydropyrimidinium chloride (5g) was determined by single-crystal X-ray diffraction. The biological properties of all novel compounds were tested and the influence of ring size and benzylic N-substituents on the biological activities were examined. Also, they were found as effective inhibitors against cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzyme. Among these compounds, 1,3-bis(4-(1-piperidinyl)benzyl)-3,4,5,6-tetrahydropyrimidinium chloride (5f) demonstrated the the best inhibition effects against hCA I, 1,3-bis(4-benzyloxy-3-methoxybenzyl)-3,4,5,6-tetrahydropyrimidinium chloride (5g) demonstrated the the best inhibition effects against cytosolic hCA II isoenzyme. On the other hand, 1,3-Bis(4-methylthiobenzyl)-3,4,5,6-tetrahydropyrimidinium chloride, (5e) demonstrated the the best inhibition effects against AChE enzyme.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1002/slct.201801019en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectCrystal structureen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectNovel imidazoliniumen_US
dc.titleNovel benzylic substituted imidazolinium, tetrahydropyrimidinium and tetrahydrodiazepinium salts: potent carbonic anhydrase and acetylcholinesterase inhibitorsen_US
dc.typearticleen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume3en_US
dc.identifier.issue27en_US
dc.identifier.startpage7976en_US
dc.identifier.endpage7982en_US


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