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dc.contributor.authorMaharramov, Abel
dc.contributor.authorKaya, Ruya
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKurbanova, Malahat
dc.contributor.authorSadigova, Arzu
dc.contributor.authorFarzaliyev, Vagif
dc.contributor.authorSujayev, Afsun
dc.contributor.authorGulçin, İlhami
dc.date.accessioned2019-04-29T08:33:27Z
dc.date.available2019-04-29T08:33:27Z
dc.date.issued2019-02
dc.identifier.urihttp://hdl.handle.net/11772/1130
dc.description.abstractIn the presence of chiral organic catalysts, the optically active 4H-chromine was synthesized from the multicomponent condensation of 5,5-dimethylcyclohexane-1,3-dione with malononitrile and methylene-active compound, and the specific angle of rotation of the compounds was determined in the AUTOPOL-III polarimeter and their structures were confirmed by the X-ray spectroscopic analysis method. These optically active 2-amino-4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-3-carbonitriles were effective inhibitors of alpha-glycosidase, the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with K-i values in the range of 21.33 +/- 1.11 to 40.24 +/- 10.78 mu M for hCA I, 28.91 +/- 6.51 to 59.97 +/- 15.62 mu M for hCA II, 18.16 +/- 3.18 to 66.57 +/- 1.36 mu M for alpha-glycosidase, and 8.68 +/- 0.93 to 102.61 +/- 24.96 mu M for AChE.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ardp.201800317en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAntidiabetic potentialen_US
dc.subjectAsymmetric synthesisen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectMetabolic enzymesen_US
dc.subjectOptically active 4H-chromenesen_US
dc.titleSynthesis, crystal structure, and biological evaluation of optically active 2‐amino‐4‐aryl‐7,7‐dimethyl‐5‐oxo‐5,6,7,8‐tetrahydro‐4H‐chromen‐3‐carbonitriles: Antiepileptic, antidiabetic, and anticholinergics potentialsen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume352en_US
dc.identifier.startpagee1800317en_US


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