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dc.contributor.authorGenç Bilgiçli, Hayriye
dc.contributor.authorKestane, Ali
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKarabay, Oguz
dc.contributor.authorBytyqi-Damoni, Arlinda
dc.contributor.authorZengin, Mustafa
dc.contributor.authorGulçin, İlhami
dc.date.accessioned2019-04-29T08:41:42Z
dc.date.available2019-04-29T08:41:42Z
dc.date.issued2019-04-16
dc.identifier.otherhttps://doi.org/10.1016/j.bioorg.2019.102931
dc.identifier.urihttp://hdl.handle.net/11772/1133
dc.description.abstractFive oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. It was concluded that these compounds are much more effective than reference drugs. These eugenol bearing oxypropanolamine derivatives were also effective inhibitors against α-glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) enzymes with Ki values in the range of 0.80 ± 0.24–3.52 ± 1.01 µM for hCA I, 1.08 ± 0.15–3.64 ± 0.92 µM for hCA II, 5.18 ± 0.84–12.46 ± 2.08 µM for α-glycosidase, and 11.33 ± 2.83–32.81 ± 9.73 µM for AChE, respectivelyen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.bioorg.2019.102931en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectEugenolen_US
dc.subjectAntibacterial effectsen_US
dc.subjectα-glycosidaseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleNovel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentialsen_US
dc.typearticleen_US
dc.relation.journalBioorganic Chemistryen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume88en_US


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