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dc.contributor.authorHuseynova, Mansura
dc.contributor.authorTaslimi, Parham
dc.contributor.authorMedjidov, Ajdar
dc.contributor.authorFarzaliyev, Vagif
dc.contributor.authorAliyeva, Mahizar
dc.contributor.authorGondolova, Gulnar
dc.contributor.authorŞahin, Onur
dc.contributor.authorYalçın, Bahattin
dc.contributor.authorSujayev, Afsun
dc.contributor.authorOrman, Efe Baturhan
dc.contributor.authorÖzkaya, Ali Rıza
dc.contributor.authorGulçin, İlhami
dc.date.accessioned2019-04-30T07:20:21Z
dc.date.available2019-04-30T07:20:21Z
dc.date.issued2018-11-15
dc.identifier.urihttp://hdl.handle.net/11772/1142
dc.description.abstractCobalt and nickel nitrates form with thiosemicarbazone of glyoxylic acid (H(2)GAT) complexes of empirical composition Co(C3H4N3O2S)(2)center dot 2H(2)O, Ni(C3H4N3O2S)(2)center dot 2H(2)O and Ni(C3H6N3O2S)(2). X-ray diffraction studies have shown that the Co(HGAT)(2)center dot 2H(2)O, Ni(HGAT)(2)center dot 2H(2)O complexes are mononuclear, in which the coordination around the metal is octahedral, made up of two sulfur atoms, two nitrogen atoms and two oxygen atoms from two ligands. By the interaction of NiCl2 center dot H2O with 2-[2-(aminothioxomethyl)hydrazinyl] acetic acid (H(2)TAA) instead of the expected the metal thiosemicarbazonate complex with the hydrogenated on the azomethine group ligand was obtained. The redox properties of these compounds were also investigated by voltammetry on Pt in dimethylsulfoxide/tetrabutylammonium perchlorate. These thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against alpha-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylcholinesterase and acetylcholinesterase. K-i values were found as 26.12-36.58 nM for hCA I, 20.73-40.78 nM for hCA II, 184.30-642.18 nM for AChE, 123.67-342.37 nM for BChE, and 14.66-45.62 nM for alpha-glycosidase. (C) 2018 Elsevier Ltd. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.poly.2018.08.026en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectCholinesteraseen_US
dc.subjectGlycosidaseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic aciden_US
dc.typearticleen_US
dc.relation.journalPolyhedronen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume155en_US
dc.identifier.startpage25en_US
dc.identifier.endpage33en_US


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