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Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes

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Date
2018-11
Author
Gulçin, İlhami
Taslimi, Parham
Aygün, Ayşenur
Sadeghian, Nastaran
Bastem, Enes
Kufrevioglu, Omer Irfan
Turkan, Fikret
Şen, Fatih
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Abstract
The glutathione S-transferase (GST) was purified from fresh blood erythrocytes using affinity column chromatography. Also, alpha-amylase from porcine pancreas and alpha-glycosidase from Saccharomyces cerevisiae were used as target enzymes. In this study, these compounds were tested on alpha-amylase, alpha-glycosidase, and GST enzymes and demonstrated effective inhibitor compounds with K-i values in the range of 8.34-40.78 mu M against GST, and 120.53-892.36 nM against alpha-glycosidase. Additionally, the phenolic molecules were tested for the inhibition of alpha-amylase enzyme which determined effective inhibition profile with IC50 values in the range of 175.01-626.58 nM. Indeed, these molecules can be elective inhibitors of GST, alpha-glycosidase and alpha-amylase enzymes as antidiabetic and antiparasitic agents. (C) 2018 Elsevier B.V. All rights reserved.
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http://hdl.handle.net/11772/1152
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