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dc.contributor.authorBehçet, Ayten
dc.contributor.authorÇağlılar, Tuba
dc.contributor.authorCelepci, DuyguBarut
dc.contributor.authorAktaş, Aydın
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGök, Yetkin
dc.contributor.authorAygün, Muhittin
dc.contributor.authorKaya, Ruya
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2019-05-06T13:22:39Z
dc.date.available2019-05-06T13:22:39Z
dc.date.issued2018-10-15
dc.identifier.urihttp://hdl.handle.net/11772/1154
dc.description.abstractThis paper reports the synthesis of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts. The benzimidazolium salts were synthesized by N-substituted benzimidazolium and aryl halides. The 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts were characterized by using H-1 NMR, C-13 NMR, FT-IR spectroscopy and elemental analysis techniques. Molecular and crystal structure of the complex 2d and 3d were obtained by single-crystal X-ray diffraction method. Additionally, The enzyme inhibition activities of the benzimidazolium salts were investigated. These 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl substituted benzimidazolium salts (1, 2a-g, and 3a-f) showed good inhibitory action against acetylcholinesterase (AChE), and human (h) carbonic anhydrase (CA) isoforms I, and II. Ki values for AChE were in range of 5.97 +/- 0.56 -23.15 +/- 3.98 nM. On the other hand, the hCA I, and II isoenzymes were effectively inhibited by these compounds, with K-i values in the range of 17.33 +/- 4.55-99.23 +/- 44.91 nM for hCA I, and 33.98 +/- 3.43 -113.23 +/- 39.31 nM for hCA II, respectively. (C) 2018 Elsevier B.V. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.molstruc.2018.05.077en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectN-heterocyclic carbenes precursorsen_US
dc.subjectBenzimidazoleen_US
dc.subjectSingle-crystal X-ray diffractionen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis, characterization and crystal structure of 2-(4-hydroxyphenyl)ethyl and 2-(4-nitrophenyl)ethyl Substituted Benzimidazole Bromide Salts: Their inhibitory properties against carbonic anhydrase and acetylcholinesteraseen_US
dc.typearticleen_US
dc.relation.journalJournal of Molecular Structureen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume1170en_US
dc.identifier.startpage160en_US
dc.identifier.endpage169en_US


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