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dc.contributor.authorTurkan, Fikret
dc.contributor.authorCetin, Adnan
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGulçin, İlhami
dc.date.accessioned2019-05-06T13:31:10Z
dc.date.available2019-05-06T13:31:10Z
dc.date.issued2018-10
dc.identifier.urihttp://hdl.handle.net/11772/1156
dc.description.abstractA series of substituteed pyrazol-4-yl-diazene derivatives were found to be effective inhibitors against -glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K-i values in the range of 33.72 +/- 7.93 to 90.56 +/- 27.52nM for -glycosidase, 1.06 +/- 0.16 to 9.83 +/- 0.74nM for hCA I, 0.68 +/- 0.12 to 7.16 +/- 1.14nM for hCA II, 44.66 +/- 10.06 to 78.34 +/- 17.83nM for AChE, and 50.36 +/- 13.88 to 88.36 +/- 20.03nM for BChE, respectively. Recently, inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances, such as diabetes, glaucoma, obesity, epilepsy, cancer, and neurodegenerative diseases.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ardp.201800200en_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectSubstituted pyrazol-4-yl-diazeneen_US
dc.titleSome pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitorsen_US
dc.typearticleen_US
dc.relation.journalArchiv der Pharmazieen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume351en_US
dc.identifier.issue10en_US
dc.identifier.startpagee1800200en_US


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