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dc.contributor.authorTaslimi, Parham
dc.contributor.authorCuneyt, Caglayan
dc.contributor.authorVagif, Farzaliyev
dc.contributor.authorOruj, Nabiyev
dc.contributor.authorAfsun, Sujayev
dc.contributor.authorFikret, Turkan
dc.contributor.authorRuya, Kaya
dc.contributor.authorIlhami, Gulcin
dc.date.accessioned2019-05-07T13:04:55Z
dc.date.available2019-05-07T13:04:55Z
dc.date.issued2018-04
dc.identifier.urihttp://hdl.handle.net/11772/1171
dc.description.abstractDuring this investigation, N,N'-bis-azidomethylamines, N,N'-bis-cyanomethylamine, new alkoxymethylamine and chiral derivatives, which are considered to be a new generation of multifunctional compounds, were synthesized, functional properties were investigated, and anticholinergic and antidiabetic properties of those compounds were studied through the laboratory tests, and it was approved that they contain physiologically active compounds rather than analogues. Novel N-bis-cyanomethylamine and alkoxymethylamine derivatives were effective inhibitors of the alpha-glycosidase, cytosolic carbonic anhydrase I and II isoforms, butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with K-i values in the range of 0.15-13.31 nM for alpha-glycosidase, 2.77-15.30 nM for human carbonic anhydrase isoenzymes I (hCA I), 3.12-21.90 nM for human carbonic anhydrase isoenzymes II (hCA II), 23.33-73.23 nM for AChE, and 3.84-48.41 nM for BChE, respectively. Indeed, the inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_US
dc.subjectN,N '-bis-cyanomethylamineen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme inhibitionen_US
dc.titleSynthesis and discovery of potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase enzymes inhibitors: The novel N,N '-bis-cyanomethylamine and alkoxymethylamine derivativesen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentBartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümüen_US
dc.identifier.volume32en_US
dc.identifier.issue4en_US
dc.identifier.startpagee22042en_US


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